Table 1.

Association between obesity-related variants and risk of contralateral breast cancer in the WECARE Study

SNPGeneChrCoordinateAllelesMAFaHWEbRRc95% CIP value
rs182052ADIPOQ3188043475G>A0.350.881.00.8, 1.10.59
rs16861205ADIPOQ3188044327G>A0.070.620.90.7, 1.20.61
rs822391ADIPOQ3188046496T>C0.20.421.00.8, 1.20.83
rs16861210ADIPOQ3188049191G>A0.090.161.00.8, 1.30.97
rs822394ADIPOQ3188049421C>A0.190.351.00.9, 1.30.75
rs12495941ADIPOQ3188050873G>T0.340.681.10.9, 1.30.16
rs7649121ADIPOQ3188051478A>T0.180.551.00.8, 1.20.77
rs9877202ADIPOQ3188052300A>G0.0010.970.50.1, 5.10.54
rs17366568ADIPOQ3188053146G>A0.130.310.90.7, 1.10.39
rs1501299ADIPOQ3188053816C>A0.270.791.10.9, 1.30.18
rs3821799ADIPOQ3188054179C>T0.470.560.90.8, 1.10.19
rs3774261ADIPOQ3188054252G>A0.40.281.00.9, 1.20.80
rs17366743ADIPOQ3188054782T>C0.030.140.80.5, 1.20.28
rs1063539ADIPOQ3188058085G>C0.130.240.90.8, 1.20.57
rs7539542ADIPOR11201176596C>G0.330.221.10.9, 1.20.51
rs2275735ADIPOR11201182177G>A0.040.670.80.5, 1.20.30
rs12045862ADIPOR11201183428C>T0.280.341.00.8, 1.20.90
rs12733285ADIPOR11201188662C>T0.30.391.00.9, 1.20.90
rs10494839ADIPOR11201188816T>C0.290.921.00.8, 1.10.65
rs10753929ADIPOR11201189800C>T0.120.701.10.9, 1.40.31
rs12132093ADIPOR11201192735G>A0.0090.761.40.7, 3.00.34
rs7514221ADIPOR11201193135T>C0.420.661.10.9, 1.30.39
rs11061925ADIPOR2121673494C>T0.320.491.00.8, 1.10.71
rs11061935ADIPOR2121684034A>G0.150.621.00.8, 1.20.69
rs7975600ADIPOR2121685512A>T0.160.901.00.8, 1.20.81
rs12826079ADIPOR2121696816C>T0.080.570.80.6, 1.10.27
rs11061946ADIPOR2121698787C>T0.070.331.10.8, 1.50.54
rs10773984ADIPOR2121701553G>A0.020.081.20.7, 1.90.49
rs11612383ADIPOR2121701615G>A0.320.911.00.8, 1.10.62
rs1058322ADIPOR2121707239C>T0.330.821.00.9, 1.20.95
rs9300298ADIPOR2121736455T>A0.50.111.00.8, 1.10.68
rs7967137ADIPOR2121740785T>C0.140.461.10.8, 1.30.69
rs12828908ADIPOR2121749645A>G0.330.021.00.8, 1.10.52
rs11061979ADIPOR2121752849T>G0.020.770.70.4, 1.10.13
rs12829901ADIPOR2121753638G>A0.020.470.60.3, 1.10.09
rs4140993ADIPOR2121759542A>C0.0060.830.40.1, 1.30.14
rs12824519ADIPOR2121761788G>A0.020.470.60.3, 1.10.08
rs1044471ADIPOR2121767216C>T0.470.001.00.9, 1.20.70
rs9532558FOXO11340031014T>C0.020.370.50.3, 0.90.03
rs2755209FOXO11340035803A>C0.390.971.10.9, 1.30.33
rs2721068FOXO11340037711T>C0.260.821.00.9, 1.20.73
rs2180961FOXO11340038043T>A0.160.111.10.9, 1.30.47
rs2755212FOXO11340041147T>C0.010.691.00.5, 2.10.98
rs2755213FOXO11340044300T>C0.10.310.90.7, 1.20.49
rs2701870FOXO11340053775G>C0.070.840.90.7, 1.30.70
rs2951787FOXO11340059769C>T0.40.170.90.8, 1.10.46
rs2984121FOXO11340059978C>G0.180.741.00.8, 1.20.75
rs4429172FOXO11340087142C>A0.310.791.00.9, 1.20.74
rs12876443FOXO11340094876T>C0.10.001.10.9, 1.40.48
rs12866643FOXO11340110731A>C0.010.601.30.7, 2.40.36
rs12874490FOXO11340115733G>C0.010.722.11.1, 3.80.02
rs1334241FOXO11340121109G>A0.210.341.10.9, 1.30.44
rs9549248FOXO11340121395A>G0.0020.930.00.98
rs9603776FOXO11340121885C>T0.030.011.10.7, 1.80.74
rs2297627FOXO11340131930T>C0.310.801.00.9, 1.20.63
rs6499640FTO1652327177A>G0.410.310.90.8, 1.10.24
rs9940646FTO1652358129C>G0.420.811.10.9, 1.30.34
rs1421085FTO1652358454T>C0.390.941.10.9, 1.30.31
rs1121980FTO1652366747C>T0.420.931.10.9, 1.30.35
rs8050136FTO1652373775C>A0.390.751.10.9, 1.30.33
rs9939609FTO1652378027T>A0.390.701.10.9, 1.30.31
rs16952624FTO1652480338C>T0.0040.990.00.98
rs7190492FTO1653828752G>A0.370.511.00.9, 1.20.94
rs1111875HHEX1094452861G>A0.410.941.00.8, 1.10.61
rs5015480HHEX1094455538C>T0.410.991.00.8, 1.10.63
rs1951795HIF1A1461241178C>A0.180.651.00.8, 1.20.82
rs10135579HIF1A1461242939A>G0.050.010.80.6, 1.10.21
rs10129270HIF1A1461251706G>A0.060.171.00.7, 1.40.98
rs4899056HIF1A1461259283C>T0.10.371.00.8, 1.20.79
rs17099141HIF1A1461263991G>A0.020.450.70.4, 1.20.23
rs2301111HIF1A1461269953C>G0.20.541.00.9, 1.30.69
rs966824HIF1A1461270270C>T0.040.471.00.7, 1.50.98
rs8012370HIF1A1461274047G>C0.0060.830.80.3, 2.10.57
rs10138153HIF1A1461274927C>T0.0060.830.80.3, 2.10.57
rs2301113HIF1A1461276300A>C0.220.651.00.8, 1.20.99
rs11549465HIF1A1461277309C>T0.10.631.10.9, 1.40.36
rs7143164HIF1A1462166755G>C0.090.380.90.7, 1.20.63
rs9912108IGF2BP11744437242T>C0.00040.991.50.1, 26.00.76
rs17635703IGF2BP11744443154A>C0.050.811.00.7, 1.30.77
rs6504592IGF2BP11744445296C>G0.060.010.80.6, 1.10.24
rs9906710IGF2BP11744446281C>A0.360.361.10.9, 1.30.34
rs17708997IGF2BP11744457036A>G0.090.341.20.9, 1.60.13
rs8073244IGF2BP11744470036C>T0.150.681.10.9, 1.30.63
rs11872073IGF2BP11744474133G>A0.030.220.60.4, 1.10.10
rs4265867IGF2BP11744478822G>A0.020.401.20.7, 1.90.54
rs2969IGF2BP11744483245C>T0.260.700.90.8, 1.10.50
rs11655950IGF2BP11744484119G>A0.320.981.10.9, 1.30.43
rs3744085IGF2BP11744486899T>C0.490.101.10.9, 1.20.45
rs4402960IGF2BP23186994380G>T0.330.061.00.9, 1.20.88
rs9515119IRS213109207336A>C0.330.080.90.8, 1.10.28
rs7996317IRS213109207931A>C0.00080.981.00.1, 6.40.96
rs754204IRS213109209568C>T0.480.721.00.9, 1.20.65
rs913949IRS213109209796A>G0.190.781.10.9, 1.30.60
rs12583454IRS213109214505G>A0.020.590.60.4, 1.10.12
rs2241745IRS213109220531A>G0.140.461.10.9, 1.40.43
rs9559648IRS213109221795C>T0.310.711.00.9, 1.20.82
rs7323191IRS213109222075A>T0.150.071.10.8, 1.30.66
rs7999797IRS213109224000A>G0.460.321.00.8, 1.10.69
rs11841502IRS213109225988G>A0.340.311.00.9, 1.20.79
rs7997595IRS213109228768C>G0.150.551.10.9, 1.30.56
rs11618950IRS213109232310G>A0.170.201.00.8, 1.20.88
rs4773092IRS213109233953G>A0.40.791.10.9, 1.30.19
rs4731426LEP7127669305C>G0.470.620.90.8, 1.10.34
rs11763517LEP7127677297T>C0.50.741.00.9, 1.20.98
rs11760956LEP7127678322G>A0.390.121.00.8, 1.10.54
rs3828942LEP7127681540G>A0.420.691.00.9, 1.150.91
rs17151919LEP7127681827G>A0.00080.980.00.98
rs12145690LEPR165659600A>C0.450.261.10.9, 1.20.54
rs4655802LEPR165660818A>G0.410.101.00.8, 1.10.69
rs9436739LEPR165663286T>A0.130.791.00.8, 1.20.81
rs9436298LEPR165663770T>A0.0070.810.60.2, 1.90.41
rs9436740LEPR165664488A>T0.280.431.10.9, 1.30.49
rs3790433LEPR165666929G>A0.260.481.10.9, 1.30.33
rs9436303LEPR165669261A>G0.250.271.00.8, 1.20.94
rs1045895LEPR165670568G>A0.40.450.80.7, 1.00.01
rs1536466LEPR165671559T>C0.0050.850.30.1, 1.20.09
rs10889552LEPR165678760C>T0.050.151.20.9, 1.70.25
rs970468LEPR165679077T>G0.360.661.21.0, 1.40.07
rs970467LEPR165679349G>A0.120.921.00.8, 1.30.73
rs17127652LEPR165707730A>G0.020.551.40.8, 2.40.24
rs6704167LEPR165710467A>T0.450.620.80.7, 1.00.01
rs7518849LEPR165721378T>C0.070.281.20.9, 1.60.17
rs6694528LEPR165735603C>T0.130.191.10.9, 1.40.25
rs7537093LEPR165739151A>G0.490.280.80.7, 1.00.02
rs6672331LEPR165748434G>C0.030.281.20.7, 1.80.54
rs11208659LEPR165751867T>C0.090.861.20.9, 1.50.16
rs1627238LEPR165758666C>T0.180.951.00.8, 1.20.93
rs1171279LEPR165761080C>T0.270.751.10.9, 1.30.43
rs1171267LEPR165776441G>T0.340.421.21.0, 1.40.03
rs1137100LEPR165809028A>G0.250.591.11.0, 1.40.13
rs3790429LEPR165809363A>T0.180.041.00.8, 1.20.70
rs13306519LEPR165810516C>G0.0040.881.40.4, 4.30.59
rs6588152LEPR165811585T>A0.220.761.00.8, 1.20.69
rs6673591LEPR165820976G>A0.520.200.90.8, 1.10.21
rs1137101LEPR165831100A>G0.430.291.10.9, 1.30.32
rs4655537LEPR165831388G>A0.370.010.90.8, 1.10.47
rs3762274LEPR165836700A>G0.380.381.10.9, 1.20.56
rs17097193LEPR165839983T>C0.030.081.10.7, 1.70.58
rs11585329LEPR165846401G>T0.160.011.00.8, 1.30.78
rs8179183LEPR165848539G>C0.180.591.00.8, 1.20.68
rs12040007LEPR165852747G>A0.180.601.10.9, 1.30.43
rs4655557LEPR165853374T>C0.380.121.10.9, 1.20.52
rs17127832LEPR165869512T>C0.190.161.00.8, 1.20.91
rs17700144MC4R1855962961G>A0.20.781.10.9, 1.30.43
rs17782313MC4R1856002076T>C0.210.401.10.9, 1.30.47
rs12970134MC4R1856035729G>A0.240.971.10.9, 1.30.51
rs17700633MC4R1856080411G>A0.280.501.00.9, 1.20.80
rs2229616MC4R1856190255G>A0.020.071.10.7, 1.80.66
rs8087522MC4R1856191457G>A0.310.451.21.0, 1.40.03
rs3101336NEGR1172523772G>A0.380.481.10.9, 1.20.49
rs2568958NEGR1172537703A>G0.380.521.10.9, 1.20.44
rs2815752NEGR1172585027T>C0.380.461.10.9, 1.20.49
rs2227562PLAU1075342966G>A0.150.411.21.0, 1.50.04
rs2227564PLAU1075343106C>T0.240.531.10.9, 1.30.21
rs4065PLAU1075346469T>C0.430.531.21.1, 1.40.01
rs344783PLAUR1934997734C>T0.480.151.00.9, 1.20.93
rs4251938PLAUR1948843460A>G0.120.040.90.7, 1.20.43
rs2302524PLAUR1948848311T>C0.160.091.00.8, 1.20.75
rs4251871PLAUR1948853337G>C0.050.521.00.7, 1.40.96
rs4251864PLAUR1948854072T>C0.090.941.10.8, 1.40.60
rs2239372PLAUR1948854793G>A0.50.761.00.9, 1.10.83
rs2283628PLAUR1948854900T>C0.180.311.10.9, 1.30.32
rs397374PLAUR1948855620A>T0.220.761.10.9, 1.30.30
rs2283632PLAUR1948856930G>A0.110.111.10.8, 1.30.68
rs4251831PLAUR1948861577G>C0.290.960.90.8, 1.10.18
rs2286960PLAUR1948863864C>T0.240.701.00.9, 1.20.83
rs1801282PPARG312368124C>G0.120.131.00.8, 1.30.97
rs6092SERPINE17100558436G>A0.110.340.90.7, 1.20.61
rs2227666SERPINE17100561424G>A0.050.771.30.9, 1.80.18
rs2227712SERPINE17100563672G>A0.0030.910.80.2, 3.10.78
rs2070682SERPINE17100563986T>C0.440.521.00.9, 1.20.61
rs2227692SERPINE17100565963C>T0.080.120.80.6, 1.10.22
rs1050813SERPINE17100568334G>A0.210.091.00.9, 1.20.83
rs2227714SERPINE17100568628C>T0.050.821.10.8, 1.60.51
rs7903146TCF7L210114748338C>T0.290.870.90.8, 1.10.42
rs2867125TMEM182612826G>A0.190.810.90.8, 1.10.53
rs6548238TMEM182624904C>T0.190.671.00.8, 1.20.83
rs4854344TMEM182628143T>G0.190.731.00.8, 1.20.85
rs7561317TMEM182634952G>A0.190.811.00.8, 1.20.81
rs10168696TMEM182662495T>C0.140.881.00.8, 1.20.76
rs2293084TMEM182665830C>A0.460.421.10.9, 1.20.50
rs2293083TMEM182666176C>G0.260.440.90.7, 1.00.07

Abbreviations: Chr, chromosome; HWE, Hardy–Weinberg equilibrium; MAF, minor allele frequency.

  • aMAF in UBC controls.

  • bHWE in UBC controls, P < 0.001.

  • cPer allele RR (log-additive model) adjusting for age at diagnosis and the counter-matching offset term.