Table 3.

Influence of quercetin-rich food intake (T3 vs. T1) on individual miR, stratified by histology and smoking status

AD
Former smokers (n = 44)Current smokers (n = 42)
miR nameT1 mean ± SDT3 mean ± SDFold changeaPbmiR nameT1 mean ± SDT3 mean ± SDFold changeaPb
hsa-mir-641−0.048 ± 0.548−0.237 ± 0.8790.8280.003hsa-mir-5800.492 ± 0.3400.226 ± 0.2860.7670.003
hsa-miR-29b−1.110 ± 1.390−1.021 ± 1.1581.0920.003hsa-miR-215−0.665 ± 0.403−0.932 ± 0.4560.7660.004
hsa-miR-146a−4.714 ± 0.805−4.830 ± 1.3340.8900.006hsa-miR-194−0.726 ± 0.662−1.159 ± 0.8830.6480.011
hsa-miR-500a0.646 ± 0.3600.471 ± 0.5390.8390.008hsa-mir-598−0.119 ± 0.498−0.674 ± 0.5380.5740.016
hsa-let-7e−1.121 ± 0.808−0.882 ± 0.8041.2700.018hsa-miR-518a-2a0.077 ± 0.3430.004 ± 0.2280.9290.020
hsa-miR-1340.404 ± 0.3040.354 ± 0.3220.9520.020hsa-miR-5030.147 ± 0.682−0.244 ± 0.4510.6770.037
hsa-miR-26b−1.624 ± 1.514−0.930 ± 1.1572.0030.021hsa-miR-146b−4.682 ± 1.234−4.278 ± 1.3881.4970.043
hsa-miR-302ca0.107 ± 0.3330.244 ± 0.3051.1470.023hsa-miR-3810.044 ± 0.432−0.127 ± 0.2690.8430.047
hsa-miR-98−1.804 ± 1.199−1.798 ± 1.5271.0060.024
hsa-let-7c−1.634 ± 1.559−1.265 ± 1.3261.4460.024
hsa-miR-27a−1.351 ± 1.218−1.097 ± 1.0021.2900.025
hsa-let-7a−2.044 ± 1.400−1.663 ± 1.2881.4640.026
hsa-let-7g−2.283 ± 1.344−2.396 ± 1.4690.8930.026
hsa-let-7i−2.153 ± 1.492−1.810 ± 1.3001.4090.028
hsa-let-7f−2.512 ± 1.587−2.191 ± 1.4331.3770.030
hsa-miR-195−2.106 ± 1.343−2.141 ± 1.1110.9660.031
hsa-miR-16−2.852 ± 1.482−2.495 ± 1.0811.4290.032
hsa-miR-146b−4.292 ± 1.012−4.254 ± 1.3361.0390.034
hsa-miR-26a−0.943 ± 1.723−0.364 ± 1.5521.7830.034
hsa-miR-19b−3.679 ± 1.048−3.947 ± 1.1080.7640.036
hsa-mir-5640.556 ± 0.2630.495 ± 0.2200.9410.037
hsa-miR-20a−4.321 ± 1.456−4.262 ± 1.0751.0610.041
hsa-miR-106a−3.747 ± 1.533−3.702 ± 0.9881.0470.044
hsa-miR-34a−0.896 ± 0.743−0.779 ± 0.5301.1240.046
hsa-miR-92a−3.729 ± 1.292−3.614 ± 1.0511.1210.048
SQ
Former smokers (n = 38)Current smokers (n = 40)
miR nameT1 mean ± SDT3 mean ± SDFold changeaPbmiR nameT1 mean ± SDT3 mean ± SDFold changeaPb
hsa-miR-492−1.383 ± 0.540−1.262 ± 0.3941.1290.012hsa-miR-5020.354 ± 0.2220.108 ± 0.2200.7820.010
hsa-miR-5100.408 ± 0.3740.166 ± 0.3070.7850.021hsa-mir-6052.198 ± 0.8611.105 ± 0.7010.3350.013
hsa-miR-491−0.274 ± 0.798−0.121 ± 0.6381.1650.023hsa-miR-5060.245 ± 0.222−0.195 ± 0.6150.6440.017
hsa-mir-612−0.264 ± 1.072−0.109 ± 0.7891.1680.025hsa-miR-1831.282 ± 0.5180.357 ± 0.3900.3970.028
hsa-miR-500a0.387 ± 0.2780.291 ± 0.3850.9080.028hsa-miR-524a0.094 ± 0.294−0.170 ± 0.1510.7680.029
hsa-mir-663−0.169 ± 0.551−0.117 ± 0.4951.0540.034
hsa-miR-503−0.069 ± 0.710−0.149 ± 0.4170.9230.034
hsa-miR-4530.584 ± 0.3240.482 ± 0.2260.9030.035
hsa-mir-654−1.239 ± 0.422−1.111 ± 0.3661.1370.041
hsa-mir-6580.211 ± 0.7930.123 ± 0.3720.9160.047

NOTE: miRs are ordered by P value within strata.

  • aFold change is the ratio (T3/T1) of geometric means (>1.0 indicates upregulation and < 1.0 downregulation).

  • bCoefficient P value from ANOVA model adjusted for age, sex, BMI, non–quercetin-rich fruits and vegetables, red/processed meat, alcohol, and cigarette packyears.