Table 3.

Influence of quercetin-rich food intake (T3 vs. T1) on individual miR, stratified by histology and smoking status

AD
Former smokers (n = 44)					Current smokers (n = 42)
miR name	T1 mean ± SD	T3 mean ± SD	Fold change^a	P^b	miR name	T1 mean ± SD	T3 mean ± SD	Fold change^a	P^b
hsa-mir-641	−0.048 ± 0.548	−0.237 ± 0.879	0.828	0.003	hsa-mir-580	0.492 ± 0.340	0.226 ± 0.286	0.767	0.003
hsa-miR-29b	−1.110 ± 1.390	−1.021 ± 1.158	1.092	0.003	hsa-miR-215	−0.665 ± 0.403	−0.932 ± 0.456	0.766	0.004
hsa-miR-146a	−4.714 ± 0.805	−4.830 ± 1.334	0.890	0.006	hsa-miR-194	−0.726 ± 0.662	−1.159 ± 0.883	0.648	0.011
hsa-miR-500a	0.646 ± 0.360	0.471 ± 0.539	0.839	0.008	hsa-mir-598	−0.119 ± 0.498	−0.674 ± 0.538	0.574	0.016
hsa-let-7e	−1.121 ± 0.808	−0.882 ± 0.804	1.270	0.018	hsa-miR-518a-2^a	0.077 ± 0.343	0.004 ± 0.228	0.929	0.020
hsa-miR-134	0.404 ± 0.304	0.354 ± 0.322	0.952	0.020	hsa-miR-503	0.147 ± 0.682	−0.244 ± 0.451	0.677	0.037
hsa-miR-26b	−1.624 ± 1.514	−0.930 ± 1.157	2.003	0.021	hsa-miR-146b	−4.682 ± 1.234	−4.278 ± 1.388	1.497	0.043
hsa-miR-302c^a	0.107 ± 0.333	0.244 ± 0.305	1.147	0.023	hsa-miR-381	0.044 ± 0.432	−0.127 ± 0.269	0.843	0.047
hsa-miR-98	−1.804 ± 1.199	−1.798 ± 1.527	1.006	0.024
hsa-let-7c	−1.634 ± 1.559	−1.265 ± 1.326	1.446	0.024
hsa-miR-27a	−1.351 ± 1.218	−1.097 ± 1.002	1.290	0.025
hsa-let-7a	−2.044 ± 1.400	−1.663 ± 1.288	1.464	0.026
hsa-let-7g	−2.283 ± 1.344	−2.396 ± 1.469	0.893	0.026
hsa-let-7i	−2.153 ± 1.492	−1.810 ± 1.300	1.409	0.028
hsa-let-7f	−2.512 ± 1.587	−2.191 ± 1.433	1.377	0.030
hsa-miR-195	−2.106 ± 1.343	−2.141 ± 1.111	0.966	0.031
hsa-miR-16	−2.852 ± 1.482	−2.495 ± 1.081	1.429	0.032
hsa-miR-146b	−4.292 ± 1.012	−4.254 ± 1.336	1.039	0.034
hsa-miR-26a	−0.943 ± 1.723	−0.364 ± 1.552	1.783	0.034
hsa-miR-19b	−3.679 ± 1.048	−3.947 ± 1.108	0.764	0.036
hsa-mir-564	0.556 ± 0.263	0.495 ± 0.220	0.941	0.037
hsa-miR-20a	−4.321 ± 1.456	−4.262 ± 1.075	1.061	0.041
hsa-miR-106a	−3.747 ± 1.533	−3.702 ± 0.988	1.047	0.044
hsa-miR-34a	−0.896 ± 0.743	−0.779 ± 0.530	1.124	0.046
hsa-miR-92a	−3.729 ± 1.292	−3.614 ± 1.051	1.121	0.048
SQ
Former smokers (n = 38)					Current smokers (n = 40)
miR name	T1 mean ± SD	T3 mean ± SD	Fold change^a	P^b	miR name	T1 mean ± SD	T3 mean ± SD	Fold change^a	P^b
hsa-miR-492	−1.383 ± 0.540	−1.262 ± 0.394	1.129	0.012	hsa-miR-502	0.354 ± 0.222	0.108 ± 0.220	0.782	0.010
hsa-miR-510	0.408 ± 0.374	0.166 ± 0.307	0.785	0.021	hsa-mir-605	2.198 ± 0.861	1.105 ± 0.701	0.335	0.013
hsa-miR-491	−0.274 ± 0.798	−0.121 ± 0.638	1.165	0.023	hsa-miR-506	0.245 ± 0.222	−0.195 ± 0.615	0.644	0.017
hsa-mir-612	−0.264 ± 1.072	−0.109 ± 0.789	1.168	0.025	hsa-miR-183	1.282 ± 0.518	0.357 ± 0.390	0.397	0.028
hsa-miR-500a	0.387 ± 0.278	0.291 ± 0.385	0.908	0.028	hsa-miR-524^a	0.094 ± 0.294	−0.170 ± 0.151	0.768	0.029
hsa-mir-663	−0.169 ± 0.551	−0.117 ± 0.495	1.054	0.034
hsa-miR-503	−0.069 ± 0.710	−0.149 ± 0.417	0.923	0.034
hsa-miR-453	0.584 ± 0.324	0.482 ± 0.226	0.903	0.035
hsa-mir-654	−1.239 ± 0.422	−1.111 ± 0.366	1.137	0.041
hsa-mir-658	0.211 ± 0.793	0.123 ± 0.372	0.916	0.047

NOTE: miRs are ordered by P value within strata.

↵^aFold change is the ratio (T3/T1) of geometric means (>1.0 indicates upregulation and < 1.0 downregulation).
↵^bCoefficient P value from ANOVA model adjusted for age, sex, BMI, non–quercetin-rich fruits and vegetables, red/processed meat, alcohol, and cigarette packyears.