Table 2.

Associations between obesity-related SNPs and papillary thyroid cancer risk

SNPRegionLocationVariantCasesControlsORaORb
RS17817288FTO52365265GG601141.00 (reference)1.00 (reference)
AG1812351.57 (1.06–2.32)1.60 (1.08–2.38)
AA99952.08 (1.33–3.25)2.14 (1.36–3.36)
Ptrend = 0.001cPtrend = 0.001c
RS11642841FTO52402988CC1561541.00 (reference)1.00 (reference)
AC1402170.65 (0.47–0.90)0.65 (0.47–0.91)
AA45730.53 (0.34–0.84)0.52 (0.33–0.83)
Ptrend = 0.002Ptrend = 0.002
RS8047395FTO52356024AA711201.00 (reference)1.00 (reference)
AG1702341.27 (0.87–1.85)1.28 (0.88–1.88)
GG100861.97 (1.28–3.05)2.03 (1.31–3.16)
Ptrend = 0.002Ptrend = 0.002
RS1121980FTO52366748GG1361371.00 (reference)1.00 (reference)
AG1552230.72 (0.52–1.01)0.70 (0.50–0.97)
AA49820.54 (0.35–0.85)0.52 (0.33–0.82)
Ptrend = 0.005Ptrend = 0.003
RS8050136FTO52373776CC1441501.00 (reference)1.00 (reference)
AC1562220.77 (0.55–1.07)0.75 (0.54–1.04)
AA41720.51 (0.32–0.81)0.49 (0.30–0.79)
Ptrend = 0.005Ptrend = 0.003
RS9939609FTO52378028TT1441511.00 (reference)1.00 (reference)
AT1552200.77 (0.56–1.07)0.75 (0.54–1.05)
AA41720.51 (0.32–0.82)0.49 (0.30–0.80)
Ptrend = 0.005Ptrend = 0.003
RS1477196FTO52365759GG1151821.00 (reference)1.00 (reference)
AG1642031.33 (0.95–1.86)1.33 (0.95–1.86)
AA60541.98 (1.24–3.13)2.00 (1.26–3.19)
Ptrend = 0.003Ptrend = 0.003
RS7202116FTO52379116AA1441511.00 (reference)1.00 (reference)
AG1562200.78 (0.56–1.08)0.76 (0.55–1.06)
GG41720.51 (0.32–0.82)0.49 (0.31–0.80)
Ptrend = 0.005Ptrend = 0.004
RS1861867FTO52406062GG1091831.00 (reference)1.00 (reference)
AG1631871.61 (1.15–2.26)1.60 (1.13–2.25)
AA68741.68 (1.09–2.59)1.73 (1.12–2.68)
Ptrend = 0.006Ptrend = 0.005
RS919275INSR7212441TT1181161.00 (reference)1.00 (reference)
CT1652420.68 (0.48–0.96)0.69 (0.49–0.97)
CC53820.54 (0.34–0.86)0.57 (0.36–0.91)
Ptrend = 0.006Ptrend = 0.011
  • aAdjusted for attained age (age at diagnosis for cases and referent age for controls; continuous), year of birth (<1940, 1940–1949, 1950+), and sex.

  • bAdjusted for attained age, year of birth, sex, and BMI (per 5 kg/m2).

  • cSNP-based linear Ptrend (unadjusted for multiple comparisons) based on modeling the 3-level genotype (0, 1, 2) as continuous in logistic regression models.