Tumor characteristics by breast cancer subtype
| Luminal A | Luminal B | Basal-like | HER2-enriched | Total | |
|---|---|---|---|---|---|
| (N = 615) | (N = 42) | (N = 210) | (N = 67) | (N = 934) | |
| N (%) | N (%) | N (%) | N (%) | N (%) | |
| Grade | |||||
| 1 | 98 (15.9) | 0 (0) | 8 (3.8) | 0 (0) | 106 (11.3) |
| 2 | 460 (74.8) | 23 (54.8) | 83 (39.5) | 28 (41.8) | 594 (63.6) |
| 3 | 54 (8.8) | 19 (45.2) | 118 (56.2) | 38 (56.7) | 229 (24.5) |
| Unknown | 3 (0.5) | 0 (0) | 1 (0.5) | 1 (1.5) | 5 (0.5) |
| P < 0.0001 | |||||
| TNM stage | |||||
| 1 | 340 (55.3) | 15 (35.7) | 82 (39.0) | 19 (28.4) | 456 (48.8) |
| 2 | 216 (35.1) | 21 (50.0) | 107 (51.0) | 37 (55.2) | 381 (40.8) |
| 3 | 28 (4.6) | 3 (7.1) | 13 (6.2) | 7 (10.4) | 51 (5.5) |
| 4 | 23 (3.7) | 1 (2.4) | 7 (3.3) | 4 (6.0) | 35 (3.7) |
| Unknown | 8 (1.3) | 2 (4.8) | 1 (0.5) | 0 (0) | 11 (1.2) |
| P < 0.0001 | |||||
| Lymph nodes | |||||
| Negative | 374 (60.8) | 20 (47.6) | 128 (61.0) | 28 (41.8) | 550 (58.9) |
| Positive | 207 (33.7) | 18 (42.9) | 71 (33.8) | 33 (49.3) | 329 (35.2) |
| Unknown | 34 (5.5) | 4 (9.5) | 11 (5.2) | 6 (9.0) | 55 (5.9) |
| P = 0.019 | |||||
| Surgical margins | |||||
| No residual tumor | 570 (92.7) | 39 (92.9) | 193 (91.9) | 63 (94.0) | 865 (92.6) |
| Microscopic residual tumor | 32 (5.2) | 1 (2.4) | 10 (4.8) | 4 (6.0) | 47 (5.0) |
| Margins not evaluable | 3 (0.5) | 1 (2.4) | 3 (1.4) | 0 (0) | 7 (0.7) |
| No primary site surgery | 4 (0.7) | 1 (2.4) | 2 (1.0) | 0 (0) | 7 (0.7) |
| Unknown | 6 (1.0) | 0 (0.0) | 2 (1.0) | 0 (0) | 8 (0.9) |
| P = 0.66 | |||||
| Histopathology | |||||
| IDC | 521 (84.7) | 37 (88.1) | 192 (91.4) | 57 (85.1) | 807 (86.4) |
| ILC | 61 (9.9) | 2 (4.8) | 12 (5.7) | 3 (4.5) | 78 (8.4) |
| Unknown/other | 33 (5.4) | 3 (7.1) | 6 (2.9) | 7 (10.4) | 49 (5.2) |
| P = 0.056 |
NOTE: P values based on χ2 test. Unknown excluded in calculation of P value. For variables with categories <5, P values are based on the Fisher exact test.
Abbreviations: IDC, Invasive ductal carcinoma; ILC, Invasive lobular carcinoma.