Table 3.

Characteristics of young (≤55 years old) patients with breast cancer according to young-like and old-like signature class, public microarray datasets from NKI, Naderi and colleagues, and UNC

NKI295Naderi and colleaguesUNC337Combined
Young-like (N)Old-like (N)P valueYoung-like (N)Old-like (N)P valueYoung-like (N)Old-like (N)P valueYoung-like (N)Old-like (N)P value
ER status
 Positive10612017152927150164
 Negative44250.028120.5231230.6987560.07
 Missing0202
Size
 <2 cm4965151712157895
 ≥2 cm101800.0410100.9548360.351591260.02
 Missing0101
Tumor grade
 Well differentiated/1314495254254
 Intermediate/2455651320107079
 Poorly differentiated/374455.0e-31190.0937300.16122840.01
 Missing1717
Subtype
 Basal31154322145732
 ERBB22029471273643
 Luminal A4244101316166873
 Luminal B4437439115751
 Normal13200.05310.66140.3417250.05
Age
 <3013003245
 30–3935242213105036
 40–491028113153125146121
 50–5512371.2e-410101.013150.8735626.5e-3