Table 5.

GO terms and pathways enriched for males among all correlating genes using Tox-Profiler

BiomarkerProcess# Significant Processes Males/FemalesT-Value MalesP-Value MalesT-Value FemalesP-Value FemalesDatabase
DR CALUX5/29
Nucleosome assembly4.10.1546.4<0.001GO
T-cell receptor signaling pathway−2.71.000−4.50.001KEGG
B-cell receptor signaling pathway−0.61.000−4.10.005KEGG
TNF-alpha-NF-kB Signaling Pathway2.90.551−4.20.010WikiPathways
ERα CALUX2/41
Immune response−1.41.0006.8<0.001GO
T-cell receptor signaling pathway−1.51.0006.8<0.001WikiPathways
B-cell receptor signaling pathway−1.91.0004.9<0.001WikiPathways
AR CALUX12/24
Immune response−2.51.000−6.6<0.001GO
Ubiquitin-dependent protein catabolic process0.91.0005.9<0.001GO
Nucleosome−4.70.020−1.21.000GO
AA Hb-adducts4/17
Translational elongation−1.71.0008.8<0.001GO
RNA splicing−5.6<0.0011.71.0000GO
GA Hb-adducts8/12
Wnt signaling pathway4.20.0320.21.000KEGG
‰MNBN30/13
Translational elongation8.5<0.001−5.7<0.001GO
Spliceosome4.60.002−5.4<0.001KEGG
mRNA processing4.00.012−4.10.002WikiPathways
Pathways in cancer4.80.0011.81.000KEGG
Translational elongation8.5<0.001−5.7<0.001GO

Only processes mentioned in the text are presented; for complete lists refer to Supplementary data Table S3.