Table 2.

Gene ontology categories enriched among age-associated genes

Ingenuity categoryP valueaMolecules
Functions annotation
Aging of cells9.4e-5NOX4, PDCD4, SOD1, TBX2, TP53
Cell flattening of cell lines9.4e-5CDKN2A, FIS1, PLD1, SMARCA4, SMARCB1
Shape change1.2e-4ANGPT1, AP1S2, ARFIP2, ARHGAP15, CASP10, CD28, CDC42EP4, CDKN2A, DLC1, EFNA1, EPHA2, EPHB4, FADD, FIS1, KITLG, MARK2, MYH9, NEDD4L, PACSIN2, PLD1, PLXNB1, RAP1B, RAP2C, ROCK2, RPS6KB1, SEMA3A, SLIT2, SMARCA4, SMARCB1, TEK, TNFSF11
Developmental process of melanocytes3.2e-4CTNNB1, EFNA1, KITLG, MITF, TP53
Nectortizing enterocolitis3.2e-4PDE11A, PDE3B, PDE4A, PDE4D, TLR4
Assembly of cellular protrusion5.8e-4ARFIP2, CCDC88A, RALA, RHOQ, SLC9A3R1, SLIT2
Retraction of cellular protrusion6.6e-4ARHGAP32, EFNA1, IL6R, ITGA3, MYH9, RHOQ, ROCK2
Canonical pathways
Role of JAK2 in hormone-like cytokine signaling1.1e-3SHC1, STAT5A, GHR, TYK2, SOCS2, JAK2
Wnt/β-catenin signaling2.9e-3TP53, SOX4, CDKN2A, SOX12, MARK2, SOX17, CSNK1E, FZD8, FZD4, SOX8, DVL2, CTNNB1, ACVR1C, WNT5B, SOX5
Ephrin receptor signaling5.2e-3RAP1B, ACTR2, EPHB4, ANGPT1, GNB2L1, LIMK2, JAK2, ITGA3, GNG7, GNG10, EFNA1, ROCK2, SHC1, SDCBP, GRIN2C, EPHA2
  • aBenjamini–Hochberg, multiple testing-adjusted P value.