Table 1.

Study population characteristics by BRAF mutation status

BRAF-wild-type (n = 1,733)BRAF-mutated (n = 247)Pa
Age at diagnosis, y
<50480 (28)29 (12)<0.001
50–59415 (24)31 (13)
60–69514 (30)105 (43)
70–74324 (19)82 (33)
Sex
Male832 (48)68 (28)<0.001
Female901 (52)179 (72)
Vital status
Alive1,078 (62)145 (59)0.29
Deceased655 (38)102 (41)
Tumor site
Proximal colon592 (35)192 (80)<0.001c
 Cecum240 (14)70 (29)<0.001d
 Ascending colon161 (10)69 (28)
 Hepatic flexure48 (3)20 (8)
 Transverse colon106 (6)27 (11)
 Splenic flexure37 (2)6 (2)
Distal colon495 (29)31 (13)
 Descending colon67 (4)6 (2)
 Sigmoid colon428 (25)25 (10)
Rectal604 (36)18 (7)
 Rectosigmoid junction151 (19)7 (3)
 Rectum453 (27)11 (5)
Stage at diagnosisb
Localized690 (40)95 (39)0.008
Regional804 (47)133 (55)
Distant211 (12)15 (6)
Unknown284
MSI statusb
MSS1,494 (90)109 (46)<0.001
MSI-H171 (10)126 (54)
Unknown6812
  • aP for χ2.

  • bPercent distribution excludes cases with unknown value of characteristic.

  • cP for χ2 of proximal/distal/rectal tumor site distribution.

  • dP for χ2 of tumor subsite distribution (e.g., cecum, ascending colon, hepatic flexure).