Table 3.

The GO terms, pathways, and networks enriched among the significantly correlating genes for the various biomarkers for males

GO term/Pathway/Network# significant processes (CC ≥ 0.60/CC ≥ 0.75)P-value (# genes affected/total # in pathway)Database
DR CALUX29/16
 Cell cycle3.76E-04 (31/679)GO
 Apoptosis5.63E-04 (26/543)GO
ERα CALUX50/9
 Antigen processing and presentation2.92E-05 (9/61)GO
 Regulation of adaptive immune response1.69E-04 (8/60)GO
AR CALUX7/1
 Cell cycle_G1-S6.64E-03 (17/122)Pathways
 Proteolysis_Ubiquitin–proteasomal proteolysis7.11E-03 (19/143)Pathways
AA Hb-adducts4/0
 Regulation of developmental process5.51E-03 (4/637)GO
 Regulation of T-cell activation8.89E-03 (2/121)GO
GA Hb-adducts0/0
‰MNBN22/53
 DNA damage_Checkpoint9.22E-03 (16/92)Networks
 Regulation of cell cyclea3.49E-04 (14/314)GO
 Apoptosis and survival_p53-dependent apoptosisa1.06E-03 (4/25)Pathways

Only processes mentioned in the text are presented; for complete lists refer to Supplementary data Table S1.

  • aFound when using the 0.75 correlation coefficient cut-off.