Table 4.

Association of prostate cancer with HOXB13 G84E in strata of age of diagnosis and disease aggressiveness

Affected in pedigreeaStratumCarrier rate (%)OR (95% CI)P
≥2≤60b8 of 435 (0.018)9.9 (1.4–68.6)0.020
≥2≥618 of 423 (0.019)7.7 (1.6–37.0)0.011
≥2Gleason ≤ 67 of 433 (0.016)6.4 (1.3–32.1)0.023
≥2Gleason ≥ 79 of 400 (0.023)9.9 (2.1–46.0)3.5 × 10−3
≥2≥pT3, N1, or M14 of 175 (0.023)9.7 (1.8–53.5)9.2 × 10−3
≥3≤605 of 177 (0.028)13.9 (1.8–105.5)0.011
≥3≥614 of 152 (0.026)10.2 (1.8–57.8)8.9 × 10−3
≥3Gleason ≤ 65 of 180 (0.028)11.3 (2.0–62.4)5.5 × 10−3
≥3Gleason ≥ 74 of 135 (0.030)13.1 (2.4–72.4)3.2 × 10−3
≥3≥pT3, N1, or M13 of 57 (0.053)23.3 (3.8–143.0)6.8 × 10−4
  • aFirst- and second-degree relatives (0, controls; 1, case probands with no others in pedigree affected; 2, case probands with one additional in pedigree affected).

  • bProband age of diagnosis.