Table 3.

Association of prostate cancer with HOXB13 G84E (rs138213197) on chromosome 17q21.32

Affected in pedigreeaCarrier rate (%)OR (95% CI)P
02 of 825 (0.002)
14 of 268 (0.015)5.6 (0.9–33.9)0.061
≥120 of 1,126 (0.018)7.2 (1.7–31.2)8.1 × 10−3
27 of 529 (0.013)5.8 (1.2–28.2)0.030
≥216 of 858 (0.019)7.9 (1.8–34.5)6.2 × 10−3
≥39 of 329 (0.027)11.8 (2.5–55.3)1.8 × 10−3
≥42 of 125 (0.016)7.0 (1.0–51.4)0.055
  • aFirst- and second-degree relatives (0, controls; 1, case probands with no others in pedigree affected; 2, case probands with one additional in pedigree affected, etc.).