Table 2.

Characteristics of HOXB13 G84E (glutamate) carriers of European descent

SubjectStatusAge diagnosis/screenPSAaPedigree typebStageGleason# Cases in pedigreecOther reported cancers in pedigreec
1Case494.6MMpT2cpN0pMX54Five additonal third-degree relatives with prostate cancer
2Case694.8MMpT2cpN0pMX74Lung, female breast, hepatocellular, colon
3Case484.1MMpT2cpN0pMX63Stomach
4Case584.0MMpT2cpN0pMX63Lung, ovary, female breast
5Case656.8MMpT2cpN0pMX63Lung, head and neck
6Case5910.8BilinealpT2cpN1pMX73None
7Case646.2MMpT2cpN0pMX73Female breast, additional unknown type
8Case553.9BilinealpT3apN0pMX53Leukemia, melanoma, pancreas, ovary, multiple myeloma
9Case664.2MMpT3apN0pMX73Lung, ovary
10Case666.3MMpT2apN0pMX72Head and neck, eye
11Case563.9MMpT2cpN0pMX62Melanoma, colon, glioma, Hodgkin's lymphoma, lung
12Case544.1MMpT2cpN0pMX72Unknown type
13Case673.4MMpT2cpNXpMX72Melanoma, leukemia
14Case615.2NMMpT2cpN0pMX62Uterine
15Case64>50NMMT2cNXMX82None
16Case5915NMMpT3bpNXpMX92Lymphoma
17Case4110.3SingletonpT2cpNXpMX71Ovary, lung
18Case688.5SingletonpT2cpN0pM051None
19Case508.1SingletonpT2cpN0pMX71Unknown type
20Case484.5SingletonpT2cpN0pMX71None
21Control801.640None
22Control560.780Cervical, lung
  • aPSA at diagnosis for case, at screen for control.

  • bMM designates apparent male-to-male transmission (autosomal dominant), whereas NMM indicates no apparent male-to-male transmission (X-linked or sibship).

  • cAmong first- and second-degree relatives.