Table 3.

Parental age in relationship to leukemia risk in offspring

Childhood ALLChildhood AMLAdult ALLAdult AML
CasesControlsOR (95% CI)CasesControlsOR (95% CI)CasesControlsOR (95% CI)CasesControlsOR (95% CI)
Unadjusted
Maternal age, y
 <20822061.17 (0.90–1.50)19601.30 (0.77–2.21)472030.92 (0.66–1.28)1205270.88 (0.72–1.08)
 20–341,8017,3071a (—)3691,5301a (—)7043,0051a (—)2,0548,9151a (—)
 ≥352931,1131.07 (0.93–1.23)652331.15 (0.85–1.55)1375530.99 (0.80–1.21)4342,0720.81b (0.72–0.90)
 Per 5-y increase1.02 (0.98–1.07)1.03 (0.94–1.14)1.00 (0.94–1.07)0.99 (0.95–1.03)
Paternal age, y
 <2014501.15 (0.63–2.09)1150.27 (0.04–2.02)8430.71 (0.33–1.52)17840.76 (0.45–1.28)
 20–341,5446,3941a (—)3171,3121a (—)5952,6031a (—)1,6337,3271a (—)
 ≥355912,2141.10 (0.99–1.22)1214840.99 (0.78–1.26)2251,0610.80c (0.68–0.94)8053,8370.78c (0.72–0.86)
 Per 5-y increase1.04c (1.00–1.09)1.08 (0.99–1.17)0.99 (0.94–1.05)1.00 (0.96–1.03)
Adjustedd
Maternal age, y
 <20822061.17 (0.89–1.53)19601.63 (0.88–3.03)472030.85 (0.59–1.25)1205271.00 (0.79–1.26)
 20–341,8017,3071a (—)3691,5301a (—)7043,0051a (—)2,0548,9151a (—)
 ≥352931,1130.98 (0.83–1.16)652330.94 (0.64–1.39)1375531.12 (0.86–1.47)4342,0720.89 (0.77–1.03)
 Per 5-y increase1.00 (0.93–1.07)0.90 (0.77–1.06)1.04 (0.93–1.16)1.01 (0.95–1.07)
Paternal age, y
 <2014501.19 (0.65–2.18)1150.30 (0.04–2.34)8430.70 (0.32–1.53)17840.90 (0.52–1.57)
 20–341,5446,3941a (—)3171,3121a (—)5952,6031a (—)1,6337,3271a (—)
 ≥355912,2141.08 (0.95–1.23)1214840.89 (0.65–1.22)2251,0610.79c (0.64–0.98)8053,8370.83c (0.74–0.94)
 Per 5-y increase1.05 (0.99–1.11)1.10 (0.96–1.26)0.97 (0.88–1.06)0.99 (0.94–1.04)
  • aReference category.

  • bP < 0.001.

  • cP < 0.05.

  • dAdjusted for sex, Down syndrome, other chromosomal aberrations, multiple birth, birth order, number of younger siblings, and mutually adjusted for maternal/paternal age.