Table 3.

Association of variants with gene expression in JBR.10 and UHN NSCLC patients

15q25 VariantJBR.10UHN
Region/gene(allele designation)aβPNβPN
15q25
CHNRB4rs16969968(G,A)−0.0840.5331290.0210.843173
rs6495309(C,T)−0.0810.631129−0.3140.011b174
rs1051730(C,T)−0.0840.5331290.0190.860174
rs12910984(A,G)−0.1070.545129−0.3390.005b176
rs578776(C,T)−0.1260.411124−0.1860.057179
rs667282(T,C)−0.0330.852129−0.3110.009b177
rs2036534(T,C)−0.1650.313129−0.2370.057172
CHRNA3rs16969968(G,A)0.0680.621129−0.0590.457173
rs6495309(C,T)0.0460.788129−0.1170.219174
rs1051730(C,T)0.0680.621129−0.0400.624174
rs12910984(A,G)0.0220.903129−0.1480.112176
rs578776(C,T)−0.1130.476124−0.0740.324179
rs667282(T,C)0.0450.801129−0.1850.041b177
rs2036534(T,C)−0.0520.755129−0.1400.146172
CHRNA5rs16969968(G,A)−0.0890.5061290.1990.059173
rs6495309(C,T)0.1830.273129−0.1140.366174
rs1051730(C,T)−0.0890.5061290.1930.070174
rs12910984(A,G)0.3700.031b129−0.1280.299176
rs578776(C,T)0.2460.107124−0.1220.213179
rs667282(T,C)0.3270.053129−0.1440.236177
rs2036534(T,C)0.2750.089129−0.1510.232172
PSMA4rs16969968(G,A)−0.2410.0751290.3220.002b173
rs6495309(C,T)0.0560.744129−0.0470.710174
rs1051730(C,T)−0.2410.0751290.3060.004b174
rs12910984(A,G)0.1230.490129−0.0830.495176
rs578776(C,T)0.3140.049b124−0.1270.192179
rs667282(T,C)0.1570.375129−0.0530.655177
rs2036534(T,C)0.1700.305129−0.0750.551172
IREB2rs16969968(G,A)−0.1170.391129−0.2490.018b173
rs6495309(C,T)0.1730.3111290.3660.004b174
rs1051730(C,T)−0.1170.391129−0.2410.024b174
rs12910984(A,G)0.2540.1501290.3610.003b176
rs578776(C,T)0.2260.1541240.2440.013b179
rs667282(T,C)0.2430.1691290.4010.001b177
rs2036534(T,C)0.3350.042b1290.3990.002b172
5p15
TERTrs401681(C,T)0.0690.6011290.0430.658174
rs4635969(C,T0.1970.2711250.1130.437166
rs402710(C,T)−0.1030.4551310.0890.383180
rs2736098(G,A)0.0810.5411280.0630.592174
rs2736100(G,T)−0.3350.008b1310.0130.909175

β, regression coefficient.

  • aMajor allele, minor allele.

  • bStatistically significant at P ≤ 0.05.