Table 2.

Univariate and multivariate models for height, sitting height, and leg length associations with breast cancer risk in the overall, pre-, and postmenopausal population, E3N cohort (N = 50,704)

Overall populationPremenopausal womenPostmenopausal women
Model 1aModel 2bModel 1aModel 2bModel 1aModel 2b
NHR (95% CI)HR (95% CI)NHR (95% CI)HR (95% CI)NHR (95% CI)HR (95% CI)
Height (cm)
<1584531 (ref)1 (ref)691 (ref)1 (ref)3841 (ref)1 (ref)
158–1625090.96 (0.85–1.09)0.96 (0.84–1.09)770.94 (0.68–1.30)0.82 (0.59–1.15)4320.98 (0.85–1.12)0.98 (0.85–1.12)
162–1653901.07 (0.93–1.23)1.07 (0.93–1.23)500.75 (0.52–1.08)0.78 (0.53–1.14)3401.14 (0.98–1.32)1.13 (0.97–1.32)
≥1657131.14 (1.02–1.29)1.15 (1.01–1.31)1100.89 (0.66–1.21)0.88 (0.63–1.23)6031.20 (1.06–1.37)1.22 (1.06–1.40)
Ptrend0.0060.0080.4220.5760.0010.002
Sitting height (cm)
<823681 (ref)1 (ref)401 (ref)1 (ref)3281 (ref)1 (ref)
82–855360.98 (0.86–1.12)0.97 (0.85–1.11)811.35 (0.92–1.98)1.19 (0.81–1.76)4550.96 (0.83–1.10)0.94 (0.81–1.08)
85–874661.02 (0.89–1.17)1.00 (0.87–1.15)701.04 (0.70–1.53)0.93 (0.62–1.39)3961.02 (0.88–1.18)0.99 (0.85–1.15)
≥876951.04 (0.91–1.18)1.02 (0.89–1.16)1151.07 (0.74–1.53)1.02 (0.70–1.49)5801.05 (0.92–1.21)1.03 (0.89–1.18)
Ptrend0.4110.640.6740.7230.2530.37
Leg length (cm)
<744571 (ref)1 (ref)721 (ref)1 (ref)3851 (ref)1 (ref)
74–775011.06 (0.94–1.21)1.06 (0.93–1.21)811.07 (0.78–1.48)1.03 (0.74–1.44)4201.06 (0.93–1.22)1.06 (0.92–1.21)
77–804951.11 (0.97–1.26)1.11 (0.97–1.27)730.97 (0.70–1.34)1.05 (0.74–1.47)4221.13 (0.98–1.30)1.13 (0.98–1.30)
≥806121.16 (1.02–1.31)1.17 (1.03–1.33)800.97 (0.70–1.33)1.00 (0.71–1.40)5321.19 (1.05–1.36)1.20 (1.05–1.38)
Ptrend0.0150.0150.7020.9820.0050.02
  • aModel 1: Unadjusted.

  • bModel 2: Adjusted for (1) non updated variables: education level (undergraduate/graduate or postgraduate), total physical activity (MET-h/wk), age at menarche (year), nulliparity (yes/no) age at first full-term pregnancy (before/after 30 years), breastfeeding (yes/no/unknown), age at menarche (year), age at menopause (year for postmenopausal women only), birth height (short, medium, large) and birth weight (low, medium, and large; (2) variables considered as time dependent: menopausal status (yes/no), use of oral contraceptives (current/non-user), family history of breast cancer (yes/no), mammography during the previous follow-up period (yes/no/unknown), history of benign breast disease (never/ever), use of oral progestagens alone before menopause (current/non-user), use of menopausal hormone therapy (MHT, current/non-user for postmenopausal women only).