Table 3.

Multivariate models for height, sitting height, and leg length associations with breast cancer risk in the overall, pre- and postmenopausal population, stratified by estrogen receptor status, E3N cohort (N = 50,704)

Overall populationaPremenopausal womenaPostmenopausal womena
ER+ERER+ERER+ER
NHR (95% CI)NHR (95% CI)NHR (95% CI)NHR (95% CI)NHR (95% CI)NHR (95% CI)
Height (cm)
<158350110314512413051791
158–1624191.04 (0.90–1.20)900.71 (0.53–0.95)570.95 (0.64–1.43)200.54 (0.29–1.01)3621.05 (0.89–1.25)700.67 (0.47–0.95)
162–1653231.17 (1.00–1.37)670.75 (0.55–1.04)411.00 (0.64–1.57)90.33 (0.14–0.77)2821.19 (1.00–1.43)580.78 (0.53–1.13)
≥1655991.28 (1.11–1.48)1140.75 (0.56–1.00)921.15 (0.77–1.71)180.35 (0.18–0.70)5071.33 (1.13–1.57)960.85 (0.61–1.19)
Ptrend<0.0010.0980.3720.003<0.0010.589
Sitting height (cm)
<8229317512911112641641
82–854300.99 (0.85–1.14)1060.91 (0.68–1.23)571.16 (0.73–1.84)241.21 (0.58–2.53)3730.99 (0.83–1.17)820.86 (0.61–1.22)
85–873871.05 (0.90–1.23)790.78 (0.57–1.07)500.91 (0.57–1.47)200.88 (0.41–1.90)3371.02 (0.86–1.22)590.72 (0.49–1.06)
≥875811.08 (0.94–1.26)1140.76 (0.56–1.03)991.23 (0.79–1.89)160.45 (0.20–1.01)4821.10 (0.93–1.30)980.86 (0.61–1.22)
Ptrend0.1580.0550.3700.0110.1860.416
Leg length (cm)
<7436519215112113141711
74–774041.08 (0.94–1.25)971.00 (0.75–1.34)621.12 (0.76–1.64)190.77 (0.40–1.47)3421.01 (0.85–1.19)781.03 (0.73–1.45)
77–804111.16 (1.01–1.34)840.92 (0.68–1.24)601.20 (0.81–1.77)130.61 (0.30–1.26)3511.07 (0.90–1.26)710.93 (0.65–1.33)
≥ 805111.22 (1.06–1.41)1010.96 (0.72–1.29)621.07 (0.72–1.59)180.76 (0.38–1.49)4491.24 (1.06–1.46)830.98 (0.69–1.39)
Ptrend0.0030.6970.7120.3650.0040.781
  • a Models were adjusted for (1) nonupdated variables: education level (undergraduate/graduate or postgraduate), total physical activity (MET-h/wk), age at menarche (year), nulliparity (yes/no) age at first full-term pregnancy (before/after 30 years), breastfeeding (yes/no/unknown), family history of breast cancer (yes/no) age at menopause (year for postmenopausal women only), birth length (short: ≤2,490 g/medium: 2,490–4,000 g/high: >4,000g), birth weight (low: ≤47cm/medium: 47–51 cm/large: >51 cm) and body shape at menarche (lean, medium, large; (2) variables considered as time-dependent: use of oral contraceptives (current/non-user), menopausal status (yes/no), mammography during the previous follow-up period (yes/no/unknown), history of benign breast disease (never/ever), use of oral progestagens alone before menopause (current/non-user), use of menopausal hormone therapy (MHT, current/non-user for postmenopausal women only).