Table 1.

Selected baseline characteristics of CRC cases (N = 1,202) according to quintile of blood 25(OH)D in the EPIC study

Blood 25(OH)D
CharacteristicQuintile 1: <36.3 nmol/L (N = 242)Quintile 2: 36.4–48.6 nmol/L (N = 239)Quintile 3: 48.7–60.5 nmol/L (N = 241)Quintile 4: 60.6–76.8 nmol/L (N = 240)Quintile 5: >76.8 nmol/L (N = 240)
25(OH)D, mean (SD), nmol/L28.5 (6.0)42.6 (3.7)54.5 (3.5)67.8 (4.4)99.3 (25.5)
Age at diagnosis, mean (SD), y62.1 (7.2)62.0 (7.1)62.5 (7.7)62.1 (7.6)62.0 (7.1)
Women, N (%)144 (59.5)128 (53.6)125 (51.9)109 (45.4)100 (41.7)
Stage of disease, N (%)
 I45 (18.6)56 (23.4)51 (21.2)48 (20.0)41 (17.1)
 II52 (21.5)43 (18.0)37 (15.4)50 (20.8)59 (24.6)
 III73 (30.2)73 (30.5)83 (34.4)71 (29.6)67 (27.9)
 IV33 (13.6)29 (12.1)23 (9.5)19 (7.9)24 (10.0)
 Unknown39 (16.1)38 (15.9)47 (19.5)52 (21.7)49 (20.4)
Grade of differentiation, N (%)
 Well differentiated12 (5.0)15 (6.3)25 (10.4)9 (3.8)13 (5.4)
 Moderately differentiated75 (31.0)76 (31.8)58 (24.1)76 (31.7)74 (30.8)
 Poorly differentiated14 (5.8)16 (6.7)23 (9.5)15 (6.3)13 (5.4)
 Unknown141 (58.3)132 (55.2)135 (56.0)140 (58.3)140 (58.3)
Location of primary tumor, N (%)
 Colon160 (66.1)145 (60.7)166 (68.9)144 (60.0)144 (60.0)
 Rectum82 (33.9)94 (39.3)75 (31.1)96 (40.0)96 (40.0)
Smoking status, N (%)
 Never smoker95 (39.3)102 (42.7)102 (42.3)100 (41.7)92 (38.3)
 Former smoker60 (24.8)72 (30.1)74 (30.7)96 (40.0)99 (41.3)
 Current smoker85 (35.1)63 (26.4)60 (24.9)44 (18.3)49 (20.4)
BMI, mean (SD), kg/m227.4 (4.9)26.9 (4.5)26.8 (4.4)26.7 (3.9)25.8 (3.7)
Physical activity, mean (SD), METs80.8 (52.8)78.7 (45.2)89.4 (57.6)83.1 (48.5)94.9 (58.0)
Dietary calcium, mean (SD), mg/d964 (412)973 (411)988 (430)1024 (470)1051 (403)
Season of blood collection
 Winter119 (49.2)96 (40.2)73 (30.3)47 (19.6)47 (19.6)
 Spring64 (26.4)60 (25.1)62 (25.7)61 (25.4)46 (19.2)
 Summer12 (5.0)24 (10.0)42 (17.7)77 (32.1)91 (37.9)
 Autumn47 (19.4)59 (24.7)64 (26.6)55 (22.9)56 (23.3)
VDR BsmI (rs1544410; 60890G>A), N (%)a
bb (GG)73 (33.2)76 (34.9)76 (34.4)75 (33.0)73 (33.6)
bB (GA)114 (51.8)103 (47.3)104 (47.1)111 (48.9)116 (53.5)
BB (AA)33 (15.0)39 (17.9)41 (18.6)41 (18.1)28 (12.9)
VDR FokI (rs2228570; 27823T>C), N (%)a
FF (CC)88 (39.6)85 (39.7)84 (38.7)85 (37.4)81 (37.7)
fF (CT)109 (49.1)99 (46.3)96 (44.2)104 (45.8)91 (42.3)
ff (TT)25 (11.3)30 (14.0)37 (17.1)38 (16.7)43 (20.0)
CASR (rs1801725, G>T; A986S), N (%)a
GG168 (73.0)167 (74.9)162 (71.4)177 (76.6)171 (75.7)
GT56 (24.4)51 (22.9)62 (27.3)49 (21.2)51 (22.6)
TT6 (2.6)5 (2.2)3 (1.3)5 (2.2)4 (1.8)

NOTE: Missing values were not excluded from percentage calculations, thus the sum of percentages across subgroups may not add up to 100%.

  • aThe number of cases for analyses of genetic variation was 1,095 for VDR FokI; 1,103 for VDR BsmI; and 1,137 for CASR due to incomplete genotyping data.