Table 1.

Baseline characteristics of study population

History of coronary artery disease
NoYesP
Number of patients, n (%)5,843 (91.4)547 (8.6)
Median age at study enrollment, y63 (58–67)66 (62–70)<0.001
Race, n (%)0.02
 White5,349 (91.2)519 (8.8)
 Black108 (92.3)9 (7.7)
 Other386 (95.3)19 (4.7)
Geographic region, n (%)0.006
 North America1,465 (92.7)115 (7.3)
 South America572 (92.3)48 (7.7)
 Europe3,520 (90.7)362 (9.3)
 Australia/New Zealand107 (87.7)15 (12.3)
 Other (Japan, Tunisia, South Africa)179 (96.2)7 (3.8)
BMI (kg/m2)26.8 (24.8–29.3)27.2 (25.2–29.7)0.003
Median PSA, ng/mL (IQR)5.7 (4.4–7.3)5.9 (4.6–7.5)0.009
Median TRUS, cc (IQR)43.3 (33.0–56.2)45.1 (34.0–57.8)0.08
PCa family history, n (%)785 (13.4)50 (9.1)0.004
Abnormal digital rectal exam, n (%)220 (3.8)21 (3.8)0.93
Assigned to Dutasteride arm, n (%)0.77
 No2,970 (50.8)281 (51.4)
 Yes2,873 (49.2)266 (48.6)
Diabetes, n (%)
 No5,523 (94.5)494 (90.3)<0.001
 Yes320 (5.5)53 (9.7)
Hypercholesterolemia, n (%)0.003
 No5,138 (87.9)404 (73.9)
 Yes705 (12.1)143 (26.1)
Hypertension, n (%)<0.001
 No4,521 (77.4)288 (52.7)
 Yes1,322 (22.6)259 (47.3)
Smoking history, n (%)0.002
 Never2,700 (46.2)223 (40.8)
 Current856 (14.7)67 (12.2)
 Former2,287 (39.1)257 (47.0)
Alcohol intake, units per week (%)0.002
 None, 0 units1,472 (25.2)136 (24.9)
 Moderate drinker, <7 units2,834 (48.5)302 (55.2)
 Heavy drinker, ≥7 units1,537 (26.3)109 (19.9)
Aspirin use, n (%)1,682 (28.8)363 (66.4)<0.001
Statin use, n (%)826 (14.1)277 (50.6)<0.001