Table 4.

The association of VDR and CASR genotypes with CRC-specific mortality in the EPIC study

Age adjustedaMultivariableb
No.EventHR (95% CI)HR (95% CI)
VDR BsmI (rs1544410)
bb (GG)3731321.00 (ref.)1.00 (ref.)
bB (GA)5482021.07 (0.86–1.33)1.01 (0.81–1.27)
BB (AA)182620.94 (0.69–1.27)1.18 (0.87–1.61)
  Ptrendc0.760.42
VDR FokI (rs2228570)
FF (CC)4231621.00 (ref.)1.00 (ref.)
fF (CT)4991780.90 (0.73–1.12)0.96 (0.77–1.19)
ff (TT)173590.81 (0.60–1.10)0.94 (0.70–1.28)
  Ptrendc0.270.90
CASR (rs1801725)
GG8453211.00 (ref.)1.00 (ref.)
GT269900.88 (0.70–1.12)0.93 (0.73–1.17)
TT2350.53 (0.22–1.28)0.47 (0.19–1.14)
  Ptrendc0.080.11

Abbreviation: ref., referent category.

  • aHRs, 95% CIs, and P values are adjusted for age at diagnosis (in years as a continuous variable) and stratified by country of residence.

  • bMultivariable HRs, 95% CIs, and P values are adjusted for age at diagnosis (in years as a continuous variable), sex (men or women), cancer stage (I–IV, unknown). Further adjustment for other covariates did not change estimates substantially.

  • cPtrend from the log-additive model.