Table 2.

HRs and 95% CIs for CRC-specific and overall mortality according to quintiles of blood 25(OH)D in the EPIC study (N = 1,202)

25(OH)D categoryCategory range, nmol/LNo.EventHR (95% CI)Ptrenda
CRC-specific mortality
 Age adjustedb
  Quintile 1<36.32421041.00 (ref.)0.02
  Quintile 236.4–48.6239850.75 (0.56–1.00)
  Quintile 348.7–60.5241950.90 (0.68–1.19)
  Quintile 460.6–76.8240780.68 (0.51–0.92)
  Quintile 5>76.8240820.69 (0.52–0.92)
 Multivariablec
  Quintile 1<36.32421041.00 (ref.)0.04
  Quintile 236.4–48.6239850.76 (0.56–1.02)
  Quintile 348.7–60.5241950.93 (0.69–1.24)
  Quintile 460.6–76.8240780.78 (0.58–1.06)
  Quintile 5>76.8240820.69 (0.50–0.93)
Overall mortality
 Age adjustedb
  Quintile 1<36.32421281.00 (ref.)<0.01
  Quintile 236.4–48.62391080.79 (0.61–1.03)
  Quintile 348.7–60.52411170.89 (0.69–1.15)
  Quintile 460.6–76.8240950.68 (0.52–0.90)
  Quintile 5>76.8240930.65 (0.49–0.84)
 Multivariablec
  Quintile 1<36.32421281.00 (ref.)<0.01
  Quintile 236.4–48.62391080.82 (0.63–1.07)
  Quintile 348.7–60.52411170.91 (0.70–1.18)
  Quintile 460.6–76.8240950.78 (0.59–1.03)
  Quintile 5>76.8240930.67 (0.50–0.88)

Abbreviation: ref., referent category.

  • aPtrend was calculated with the median value of each 25(OH)D category as a continuous variable, adjusted for variables in the corresponding models.

  • bHRs, 95% CIs, and P values are adjusted for age at diagnosis (in years as a continuous variable) and stratified by country of residence.

  • cMultivariable HRs, 95% CIs, and P values are adjusted for age at diagnosis (in years as a continuous variable), sex (men or women), cancer stage (I–IV, unknown), grade of tumor differentiation (well differentiated, moderately differentiated, poorly differentiated, or unknown), location of primary tumor (colon or rectum), smoking status (current, former, never smoker, or unknown), BMI (in kg/m2 as a continuous variable), physical activity (in METs as a continuous variable), season of blood collection (winter, spring, summer, and autumn), and year of diagnosis (as a continuous variable), and stratified by country of residence.