Table 5.

Impact of risk reducing surgery on psychosocial outcomes among BRCA1/2 mutation carriers

VariableTotal R2ΔR2dfFinal β
Impact of risk reducing mastectomy
Perceived breast cancer risk
Model 10.05a0.05a3, 117
 Affected status−0.15a
 Pretest cancer distress0.01
 Pretest anxiety0.18a
Model 20.23b0.18b4, 116
 Risk reducing mastectomy−0.44b
Impact of risk reducing oophorectomy
Perceived breast cancer risk
Model 10.08c0.08c5, 105
 Affected status−0.26c
 Pretest cancer distress−0.01
 Pretest anxiety0.11
Model 20.11a0.02a4, 104
 Risk reducing oophorectomy−0.16a
Perceived ovarian cancer risk
Model 10.06c0.06c1,113
 Age0.07
Model 20.30b0.24b2, 112
 Risk reducing oophorectomy−0.58b
Genetic testing distress
Model 10.14c0.14c4, 112
 Education0.08
 Total relatives with breast/ovarian cancer−0.16c
 Pretest cancer distress0.33c
 Pretest anxiety−0.06
Model 20.16c0.02d5, 111
 Risk reducing oophorectomy−0.16a

NOTE: Bivariate predictors (P < 0.10) were entered in Model 1. For RRM outcomes, RRM was entered in Model 2 and the change in R2 was tested for significance. Reference for RRM is no RRM. For RRBSO outcomes, RRBSO was entered in Model 2 and the change in R2 was tested for significance. Reference for RRBSO is no RRBSO.