Table 2.

Top findings from association tests in the entire population

GeneSNPLocationRisk alleleNominal POR (95% CI)
MTHFD1rs11627387IVS26-955G>AG0.00270.84 (0.75–0.94)
GLSrs12185688IVS14-3683T>CT0.00330.79 (0.67–0.92)
MTHFD1rs2230491Ex1-1015C>TC0.00450.80 (0.69–0.93)
UNG2rs231625-4520T>CC0.00881.26 (1.06–1.50)
TYMSrs2298582IVS13+122A>CA0.00900.80 (0.67–0.95)
MTHFSrs622506IVS2-1411T>GG0.01211.15 (1.03–1.28)
MTHFD1rs2281603IVS27-380T>CT0.01380.85 (0.75–0.97)
GARTrs9984077Ex11+195G>AA0.01381.17 (1.03–1.34)
UNG2rs231622IVS1+5C>TT0.01411.16 (1.03–1.30)
MTHFD2rs7587117IVS29-27A>GG0.01461.15 (1.03–1.29)