Top findings from association tests in the entire population
| Gene | SNP | Location | Risk allele | Nominal P | OR (95% CI) |
|---|---|---|---|---|---|
| MTHFD1 | rs11627387 | IVS26-955G>A | G | 0.0027 | 0.84 (0.75–0.94) |
| GLS | rs12185688 | IVS14-3683T>C | T | 0.0033 | 0.79 (0.67–0.92) |
| MTHFD1 | rs2230491 | Ex1-1015C>T | C | 0.0045 | 0.80 (0.69–0.93) |
| UNG2 | rs231625 | -4520T>C | C | 0.0088 | 1.26 (1.06–1.50) |
| TYMS | rs2298582 | IVS13+122A>C | A | 0.0090 | 0.80 (0.67–0.95) |
| MTHFS | rs622506 | IVS2-1411T>G | G | 0.0121 | 1.15 (1.03–1.28) |
| MTHFD1 | rs2281603 | IVS27-380T>C | T | 0.0138 | 0.85 (0.75–0.97) |
| GART | rs9984077 | Ex11+195G>A | A | 0.0138 | 1.17 (1.03–1.34) |
| UNG2 | rs231622 | IVS1+5C>T | T | 0.0141 | 1.16 (1.03–1.30) |
| MTHFD2 | rs7587117 | IVS29-27A>G | G | 0.0146 | 1.15 (1.03–1.29) |