Table 3.

Top findings from association tests in each quartile of prefortification dietary folate

GeneSNPLocationRisk alleleDietary folate quartileNominal PaOR per allele95% CI
ADArs244072IVS2-1496T>CC12.37E-05b2.331.60–3.50
20.71941.070.75–1.50
30.49521.150.77–1.70
40.93980.990.68–1.40
FOLR1rs105014097502T>GT10.00101.771.25–2.50
20.80141.050.74–1.48
30.81050.960.72–1.52
40.31341.220.83–1.81
TYMSrs11664283−6774A>GA10.00161.451.15–1.85
20.05980.790.63–1.01
30.36901.120.91–1.45
40.95891.010.77–1.30
CDO1rs34869−599C>GC10.00181.411.14–1.75
20.01771.311.05–1.64
30.13111.200.66–1.06
40.40690.900.71–1.15
MAT2Brs4869087IVS2-1783C>AC10.79001.030.81–1.30
20.15791.180.94–1.50
30.00200.650.49–0.86
40.28271.160.89–1.50

NOTE: P value that is the most significant in each SNP is marked bold.

  • aNominal P before adjustment for multiple comparisons.

  • bP value that is statistically significant (P < 0.05) after adjustment for multiple testing.