Table 3.

Top findings from association tests in each quartile of prefortification dietary folate

Gene	SNP	Location	Risk allele	Dietary folate quartile	Nominal P^a	OR per allele	95% CI
ADA	rs244072	IVS2-1496T>C	C	1	2.37E-05^b	2.33	1.60–3.50
				2	0.7194	1.07	0.75–1.50
				3	0.4952	1.15	0.77–1.70
				4	0.9398	0.99	0.68–1.40
FOLR1	rs10501409	7502T>G	T	1	0.0010	1.77	1.25–2.50
				2	0.8014	1.05	0.74–1.48
				3	0.8105	0.96	0.72–1.52
				4	0.3134	1.22	0.83–1.81
TYMS	rs11664283	−6774A>G	A	1	0.0016	1.45	1.15–1.85
				2	0.0598	0.79	0.63–1.01
				3	0.3690	1.12	0.91–1.45
				4	0.9589	1.01	0.77–1.30
CDO1	rs34869	−599C>G	C	1	0.0018	1.41	1.14–1.75
				2	0.0177	1.31	1.05–1.64
				3	0.1311	1.20	0.66–1.06
				4	0.4069	0.90	0.71–1.15
MAT2B	rs4869087	IVS2-1783C>A	C	1	0.7900	1.03	0.81–1.30
				2	0.1579	1.18	0.94–1.50
				3	0.0020	0.65	0.49–0.86
				4	0.2827	1.16	0.89–1.50

NOTE: P value that is the most significant in each SNP is marked bold.

↵^aNominal P before adjustment for multiple comparisons.
↵^bP value that is statistically significant (P < 0.05) after adjustment for multiple testing.