Table 1.

Characteristics of diabetic patients with colorectal cancer and their controls

Cases (%; n = 920)Controls (%; n = 5,520)Crude OR (95% CI)Adjusted ORa (95% CI)
Age (y)
 <401 (0.1)5 (0.1)
 40–4918 (2.0)114 (2.1)
 50–5979 (8.6)492 (8.9)
 60–69296 (32.2)1,742 (31.6)
 70–79390 (42.4)2,365 (42.8)
 ≥80136 (14.8)802 (14.5)
Sex
 Male582 (63.3)3,492 (63.3)
 Female338 (36.7)2,028 (36.7)
Smoking
 Nonsmoker458 (49.8)2,621 (47.5)1.00 (referent)1.00 (referent)
 Current89 (9.7)759 (13.8)0.66 (0.52–0.85)0.68 (0.53–0.87)
 Past283 (30.8)1,590 (28.8)1.02 (0.86–1.21)1.03 (0.87–1.22)
 Unknown90 (9.8)550 (10.0)0.93 (0.72–1.20)0.90 (0.65–1.23)
BMI
 <25147 (16.0)1,071 (19.4)1.00 (referent)1.00 (referent)
 25–29.9338 (36.7)1,936 (35.1)1.28 (1.04–1.57)1.27 (1.03–1.57)
 ≥30316 (34.4)1,773 (32.1)1.32 (1.06–1.63)1.34 (1.08–1.68)
 Unknown119 (12.9)740 (13.9)1.16 (0.89–1.52)1.15 (0.84–1.58)
Comorbidities
 CHF74 (8.0)519 (9.4)0.84 (0.65–1.09)0.89 (0.69–1.17)
 IHD239 (26.0)1,533 (27.8)0.91 (0.77–1.07)1.05 (0.88–1.27)
 Stroke/TIA91 (9.9)650 (11.8)0.82 (0.65–1.04)0.91 (0.72–1.16)
 Hypertension545 (59.2)3,161 (57.3)1.09 (0.94–1.27)1.08 (0.93–1.26)
 Dyslipidemia208 (22.6)1,248 (22.6)1.00 (0.84–1.20)1.03 (0.85–1.26)
Acetylsalicylic acid use
 No use557 (60.5)3,056 (55.4)1.00 (referent)1.00 (referent)
 1–14 prescriptions171 (18.6)1,021 (18.5)0.90 (0.74–1.09)0.89 (0.72–1.09)
 ≥15 prescriptions192 (20.9)1,443 (26.1)0.69 (0.57–0.84)0.69 (0.55–0.85)
NSAID use
 No use407 (44.2)2,281 (41.3)1.00 (referent)1.00 (referent)
 1–9 prescriptions373 (40.5)2,170 (39.3)0.95 (0.81–1.11)0.95 (0.80–1.16)
 ≥10 prescriptions140 (15.2)1,069 (19.4)0.72 (0.58–0.89)0.70 (0.57–0.88)
Estrogen use (women only)
 No use294 (87.0)1,731 (85.4)1.00 (referent)1.00 (referent)
 1–14 prescriptions24 (7.1)144 (7.1)0.96 (0.60–1.54)0.98 (0.61–1.57)
 ≥15 prescriptions20 (5.9)153 (7.5)0.74 (0.45–1.24)0.78 (0.47–1.31)
Statin use
 No use580 (63.0)3,438 (62.3)1.00 (referent)1.00 (referent)
 1–9 prescriptions156 (17.0)891 (16.1)1.02 (0.82–1.26)1.02 (0.81–1.28)
 ≥10 prescriptions184 (20.0)1191 (21.6)0.89 (0.72–1.10)0.96 (0.75–1.22)
  • aAdjusted for all other variable in the table (estrogens women only).

    CHF = congestive heart failure; IHD = ischemic heart disease; TIA = transient ischemic attack.