Table 1.

Comparisons of the ROC-AUCs for CA125 and HE4 across the groups enrolled in this study

CA125 ROC-AUC (95% CI)HE4 ROC-AUC (95% CI)P
Postmenopause
 EOC vs. HC0.9940 (0.9866–1.0000)0.9576 (0.9279–0.9873)0.0147
 EOC vs. cysts0.9602 (0.9353–0.9852)0.9400 (0.9039–0.97599)0.2439
 Cysts vs. HC0.6671 (0.5898–0.7444)0.5856 (0.5055–0.6656)0.1420
Premenopause
 EOC vs. HC0.9773 (0.9457–1.0000)0.9177 (0.8279–1.0000)0.1233
 EOC vs. cysts0.9549 (0.9053–1.0000)0.9016 (0.8068–0.9965)0.1867
 EOC vs. end0.8473 (0.7397–0.9549)0.8925 (0.7907–0.9944)0.3211
 Cysts vs. HC0.5960 (0.4644–0.7275)0.5744 (0.4390–0.7097)0.8280
 End vs. HC0.8982 (0.8183–0.9781)0.6369 (0.5055–0.7682)0.0011
 End vs. cysts0.8361 (0.7307–0.9416)0.5471 (0.4075–0.6867)0.0019

NOTE: “Cysts” refers to patients with ovarian benign cysts and “end” refers to patients with endometriosis.

Abbreviation: HC, healthy controls.