Table 1.

AR-binding SNPs associated with prostate cancer risk from the 2 GWAS datasets (CGEMS and JHH) at P ≤ 0.001a

JHHCGEMSCombined
MAFMAF
SNPCHRBPbAllelesMinor alleleCaseCtrlOR (95% CI)PCaseCtrlOR (95% CI)POR (95% CI)PLDKnown risk SNPscConfd
rs67036701p36.237,953,443A/GA0.010.020.63 (0.45–0.87)5.16E-030.010.020.66 (0.41–1.04)0.070.64 (0.49–0.83)9.09E-041Yes
rs37652271q24.2167,703,777A/CA0.050.060.75 (0.62–0.90)2.29E-030.030.050.70 (0.52–0.94)0.020.73 (0.63–0.86)1.26E-042Yes
rs37376831q24.2167,704,804G/AG0.050.060.75 (0.62–0.90)2.31E-030.030.050.70 (0.52–0.94)0.020.73 (0.63–0.86)1.27E-042
rs67125272q33.3208,588,496C/TC0.260.251.09 (0.99–1.21)0.080.300.251.27 (1.11–1.44)4.02E-041.15 (1.07–1.25)3.76E-043Yes
rs75699182q34213,592,762T/CT0.290.261.13 (1.03–1.24)0.010.290.261.16 (1.01–1.32)0.031.14 (1.05–1.23)8.85E-044Yes
rs76401453q22.3140,216,904G/AG0.150.170.86 (0.77–0.97)0.010.150.190.76 (0.65–0.89)6.48E-040.83 (0.76 - 0.91)4.55E-055Yes
rs131348694q31.21144,922,904G/AG0.320.350.85 (0.78–0.93)2.51E-040.330.340.96 (0.85–1.09)0.530.88 (0.82–0.95)7.78E-046Yes
rs29409195p1242,506,487G/AG0.210.191.13 (1.02–1.26)0.020.210.181.24 (1.07–1.44)4.52E-031.17 (1.07 - 1.27)3.77E-047
rs29409205p1242,507,356C/TC0.210.191.13 (1.02–1.26)0.020.210.181.24 (1.07–1.44)4.52E-031.17 (1.07–1.27)3.76E-047Yes
rs119556815q31.3142,920,885A/TA0.160.131.28 (1.14–1.44)6.05E-050.170.161.05 (0.89–1.23)0.591.19 (1.08 - 1.31)3.95E-048Yes
rs122137036p22.322,929,929A/GA0.110.091.31 (1.14–1.50)9.50E-050.100.091.06 (0.87–1.29)0.581.22 (1.09–1.37)4.14E-049Yes
rs171560417p15.227,942,270T/CT0.200.220.85 (0.77–0.94)1.89E-030.190.210.87 (0.76–1.01)0.070.86 (0.79 - 0.93)3.19E-0410rs10486567
rs104865677p15.227,943,088A/GA0.210.240.86 (0.78–0.94)2.01E-030.210.230.87 (0.76–1.00)0.060.86 (0.79–0.93)2.83E-0410rs10486567
rs13982408p21.223,557,551C/AC0.430.391.19 (1.10–1.30)3.14E-050.420.411.08 (0.95–1.22)0.231.15 (1.08 - 1.24)4.00E-0511rs1512268
rs11602678p21.223,585,466G/AG0.460.421.22 (1.12–1.32)3.28E-060.440.431.06 (0.94–1.19)0.371.16 (1.09–1.24)1.34E-0511rs1512268
rs132591318q24.13124,106,137T/CT0.430.391.19 (1.09–1.30)6.08E-050.410.391.09 (0.96–1.22)0.191.15 (1.08–1.24)5.25E-0512Yes
rs78244518q24.21128,183,643G/CG0.040.031.66 (1.33–2.07)8.44E-060.040.031.23 (0.91–1.66)0.191.49 (1.25–1.79)1.22E-0513rs16901979
rs78124298q24.21128,589,355A/GA0.120.091.36 (1.19–1.54)4.12E-060.140.101.52 (1.27–1.82)6.38E-061.41 (1.27 - 1.56)1.87E-1014rs1447295
rs78128948q24.21128,589,661A/TA0.120.091.36 (1.19–1.54)4.12E-060.140.101.52 (1.27–1.82)6.38E-061.41 (1.27–1.56)1.87E-1014rs1447295
rs100994138q24.21128,591,245T/CT0.150.121.26 (1.12–1.42)9.28E-050.180.131.44 (1.22–1.70)1.41E-051.32 (1.20 - 1.45)1.20E-0814rs1447295
rs78148378q24.21128,591,384T/GT0.120.091.36 (1.19–1.54)4.12E-060.140.101.52 (1.27–1.82)6.38E-061.41 (1.27–1.56)1.87E-1014rs1447295
rs24725378q24.22133,929,827G/AG0.240.211.19 (1.08–1.31)6.59E-040.230.211.12 (0.97–1.29)0.111.16 (1.07 - 1.26)2.12E-0415Yes
rs47413049p2313,478,608G/TG0.140.121.19 (1.05–1.34)5.55E-030.140.111.24 (1.03–1.48)0.021.20 (1.09–1.33)3.26E-0416Yes
rs707569710q11.2351,217,377C/GC0.500.451.25 (1.14–1.36)6.80E-070.460.411.23 (1.10–1.39)5.55E-041.24 (1.16 - 1.33)1.46E-0917rs10993994
rs1222391611q22.199,969,463G/CG0.100.120.87 (0.76–0.99)0.040.100.120.77 (0.64–0.93)6.19E-030.83 (0.75–0.93)9.94E-0418
rs1122433511q22.1100,008,564T/CT0.090.110.84 (0.73–0.97)0.010.090.120.75 (0.62–0.91)3.90E-030.81 (0.73 - 0.91)2.58E-0418Yes
rs1122433611q22.1100,008,742A/GA0.090.110.84 (0.73–0.97)0.010.090.120.75 (0.62–0.92)4.42E-030.81 (0.73–0.91)2.74E-0418
rs712244211q22.3107,983,350G/AG0.030.040.73 (0.58–0.94)0.010.020.030.57 (0.38–0.87)8.78E-030.69 (0.56 - 0.85)5.17E-0419Yes
rs491974312q13.1351,595,851A/GA0.130.111.21 (1.06–1.37)4.34E-030.140.121.22 (1.02–1.46)0.031.21 (1.09–1.34)3.64E-0420Yes
rs959510013q14.1143,783,474G/AG0.230.250.90 (0.82–0.99)0.030.220.260.83 (0.72–0.95)7.49E-030.88 (0.81–0.95)9.35E-0421Yes
rs381354614q24.375,689,714G/AG0.210.191.14 (1.03–1.27)0.010.200.171.20 (1.03–1.39)0.021.16 (1.06–1.26)7.42E-0422Yes
rs1695680115q13.329,579,883A/CA0.160.131.28 (1.14–1.44)3.72E-050.150.141.09 (0.92–1.29)0.321.21 (1.10–1.34)7.65E-0523Yes
rs1291853916p12.317,386,896T/CT0.370.390.91 (0.84–1.00)0.040.340.380.83 (0.73–0.94)3.00E-030.89 (0.83–0.95)7.38E-0424Yes
rs807155817q24.366,619,268G/CG0.480.520.85 (0.79–0.93)1.48E-040.470.520.84 (0.75–0.94)2.45E-030.85 (0.79–0.91)1.25E-0625rs1859962
rs807225417q24.366,619,411G/AG0.480.520.85 (0.79–0.93)1.48E-040.470.520.84 (0.75–0.94)2.45E-030.85 (0.79–0.91)1.25E-0625rs1859962
rs98443417q24.366,619,722C/TC0.480.520.85 (0.79–0.93)1.48E-040.470.520.84 (0.74–0.94)2.21E-030.85 (0.79–0.91)1.15E-0625rs1859962
rs185996217q24.366,620,348T/GT0.480.520.86 (0.79–0.93)2.61E-040.470.510.84 (0.75–0.94)2.42E-030.85 (0.80–0.91)2.28E-0625rs1859962
rs807790617q24.366,623,828A/GA0.310.330.91 (0.84–1.00)0.040.320.360.83 (0.74–0.94)3.39E-030.88 (0.82–0.95)7.45E-0425rs1859962
rs808709518q21.249,551,741A/GA0.200.230.86 (0.78–0.95)3.49E-030.230.250.89 (0.77–1.02)0.100.87 (0.80–0.94)8.25E-0426Yes
rs603600720p11.2221,922,590C/TC0.430.460.91 (0.84–0.99)0.030.420.470.84 (0.75–0.94)3.49E-030.89 (0.83–0.95)4.67E-0427
rs20154820p11.2221,922,835C/TC0.430.460.91 (0.84–0.99)0.030.420.470.84 (0.75–0.94)3.49E-030.89 (0.83–0.95)4.67E-0427Yes
rs610643820p11.2221,923,026C/TC0.430.460.91 (0.84–0.99)0.030.420.470.84 (0.75–0.95)4.30E-030.89 (0.83–0.95)5.38E-0427
rs602225720q11.2336,052,672T/CT0.160.190.82 (0.74–0.92)4.96E-040.170.190.87 (0.74–1.01)0.070.84 (0.77–0.92)1.06E-0428Yes
rs602225920q11.2336,052,895T/CT0.160.190.83 (0.75–0.93)1.02E-030.170.190.87 (0.74–1.01)0.070.85 (0.77–0.92)2.02E-0428
rs289933422q13.138,881,796T/CT0.400.440.86 (0.79–0.93)2.61E-040.400.410.96 (0.85–1.08)0.450.89 (0.83–0.95)6.39E-0429
rs600183122q13.138,921,204T/GT0.400.440.86 (0.79–0.93)2.66E-040.400.410.95 (0.85–1.07)0.430.89 (0.83–0.95)6.16E-0429Yes
  • aThe P values and OR for each SNP were calculated based on multiplicative models. SNPs were listed according to their chromosomal positions and organized based on the LD blocks (r2> = 0.5) where they are located.

  • bThe base position (BP) of each SNP was based on NCBI build 36.

  • cKnown risk SNPs were selected from consensual PCa risk-associated SNPs which are in LD (r2> = 0.5) with the SNPs under investigation (3–16).

  • dSNPs that were selected for confirmation (“Conf”) were labeled as “Yes.” Abbreviations: CHR, chromosome; Ctrl, control subjects.