Table 4.

Selected haplotypea main effects on SCCHN risk, additive genetic model

Gene (haplotype definition)HaplotypeRaceb (% prevalence)OR (95% CI)c
ALDH2 (rs4767939, rs2238151, rs7312055, rs2158029, rs16941667, rs16941669)ACAGCTAA (26)1.0 (ref)
ATGGCTAA (11)0.5 (0.3–0.8)
CYP2E1 (rs915908, rs7092584, rs743535, rs2249695)GCCCEA (65)1.0 (ref)
GCCTEA (10)0.7 (0.6–0.9)
GPX2 (rs11623705, rs2412065, rs2737844)GGCEA (70)1.0 (ref)
GCTEA (9)0.7 (0.5–0.9)
SOD1 (rs4998557, rs10432782, rs2070424, rs1041740)GTACEA (58)1.0 (ref)
AGGCEA (6)1.4 (1.1–1.9)
GTACAA (52)1.0 (ref)
AGGCAA (6)0.6 (0.4–0.9)
  • aCriterion for selecting haplotypes for this table: ORs were statistically significant, or nearly so, after Bonferroni correction for multiple testing (13 for EA, 12 for AA)

  • bAA, African-American (black), EA, European-American (Caucasian/white).

  • cUnconditional logistic regression models for estimating main effect of each haplotype were adjusted for matching variables sex and age category and their 2-way interaction, and for continuous smoking duration rounded to whole years. The referent group for each OR was the most common haplotype. ORs highlighted in BOLD are statistically significant after Bonferroni correction of P-value.