Table 2.

Levels of SP-D and KL-6 among matched controls in the PLCO Cancer Screening Trial

 SP-D (ng/mL)KL-6 (μg/mL)
Geometric mean95% CIPcGeometric mean95% CIPc
Age at randomization, y
 ≤5994.685.2–105.00.08344.6314.9–377.20.26
 60–64105.396.9–114.5337.1313.7–362.4
 65–69101.093.3–109.3342.1319.6–366.3
 70+110.6100.8–121.3366.4338.2–396.8
Gender
 Male108.1102.3–114.20.004361.4344.8–378.90.003
 Female94.587.7–101.8320.8300.9–341.9
Race
 White108.6103.8–113.5<0.0001347.7334.0–362.00.38
 Black74.261.1–90.0372.4312.9–443.2
 Asian57.237.7–86.9297.8204.5–433.8
 Pacific Islander56.645.3–70.7316.1258.6–386.5
 American Indian41.620.2–85.7214.3111.8–411.0
Smoking status
 Never92.983.9–102.90.03334.2306.0–365.00.41
 Current110.3102.4–118.8341.0319.8–363.6
 Former102.195.7–109.0356.1336.6–376.8
Cigarettes smoked per daya
 10–20101.395.4–107.50.91348.1330.7–366.40.57
 21–30106.196.6–116.6345.3318.3–374.5
 31–40104.391.9–118.4342.2306.9–381.5
 41–100105.491.2–121.8346.2305.7–392.1
Cumulative smoking, pack-yearsa
 1–3093.384.6–102.90.06360.6331.2–392.70.66
 30–40113.0102.8–124.3335.4308.8–364.4
 40–50104.088.7–121.9387.9337.7–445.5
 50–230109.7101.4–118.7343.3320.5–367.6
Years since quittingb
 0.5–15104.095.8–112.90.47357.4332.0–384.80.87
 15–5399.089.1–110.1354.0321.8–389.4
BMI
 14.0–25.0111.5103.2–120.40.03353.5330.7–378.00.38
 25.1–30.099.493.2–106.1345.9326.9–366.0
 30.1–52.598.088.6–108.4336.7308.5–367.4
History of chronic bronchitis
 No102.697.9–107.40.41346.1332.6–360.10.73
 Yes110.293.4–130.0355.2308.1–409.5
History of emphysema
 No102.597.9–107.30.33346.9333.6–360.80.73
 Yes113.193.3–137.1336.9285.4–397.5
Regular aspirin use
 No101.394.9–108.20.48348.7329.7–368.80.77
 Yes104.798.5–111.2344.7327.2–363.2
Regular ibuprofen use
 No106.2100.7–112.00.05350.6334.8–367.10.38
 Yes96.589.2–104.5337.8315.4–361.7
CRP, mg/L
 0.30–0.9997.588.6–107.20.11321.2296.0–348.40.04
 1.0–2.4102.794.4–111.8351.0326.3–377.5
 2.5–5.3102.894.1–112.2345.3320.2–372.3
 5.4–147.0109.099.8–119.1366.4339.7–395.3
  • aAnalysis was limited to former and current smokers only.

  • bAnalysis was limited to former smokers only.

  • cP value is for overall difference or trend.