Table 5.

Additive interactive effects of alcohol with selected SNPsa

Homozygous for major alleleOne or two copies of minor allele
Gene, SNP, major/minor allelesLifetime ethanol, mLNo. of cases/controlsAdjusted OR (95% CI)bNo. of cases/controlsAdjusted OR (95% CI)bICRc (CIBonferroni corrected)
ALDH2, rs2238151, T/C
Never-drinkers50/951.0 (ref)67/1840.7 (0.4–1.1)1.9 (0.1–3.8)
>0 to <134,69975/1730.5 (0.3–0.9)133/2930.6 (0.4–1.0)
134,699 to <757,55097/1380.8 (0.5–1.3)220/2221.2 (0.8–1.9)
757,550+122/651.7 (1.0–2.8)381/1063.3 (2.0–5.3)
ADH1B, rs1159918, G/T
Never-drinkers49/1011.0 (ref)68/1790.9 (0.6-1.5)1.0 (-0.9 to 3.0)
>0 to <134,69980/1680.7 (0.4-1.1)129/2980.7 (0.5-1.1)
134,699 to <757,550107/1291.1 (0.7-1.8)211/2311.3 (0.8-2.0)
757,550+140/582.4 (1.4–4.1)365/1153.3 (2.1-5.4)
ADH7, rs1154460, G/A
Never-drinkers35/651.0 (ref)81/2150.6 (0.4-1.1)0.9 (-0.6 to 2.4)
>0 to <134,69957/1310.5 (0.3-0.9)152/3340.6 (0.3-0.9)
134,699 to <757,55088/1110.8 (0.5-1.4)229/2491.0 (0.6-1.6)
757,550+133/541.9 (1.1-3.5)371/1192.5 (1.5-4.2)
CYP2E1, rs2249695, C/T
Never-drinkers73/1361.0 (ref)44/1440.6 (0.4–0.9)1.2 (-0.6 to 3.0)
>0 to <134,699127/2530.6 (0.4–0.9)82/2130.5 (0.3–0.8)
134,699 to <757,550160/1781.1 (0.7–1.6)158/1811.0 (0.6–1.4)
757,550+218/922.1 (1.4–3.3)286/812.9 (1.8–4.6)
  • aSelected SNPs meet two criteria. They have (1) ICR confidence interval that either does not include 0 or nearly so, after Bonferroni correction, and (2) genotype information on sufficient numbers of cases and controls (at least 10 each) for calculating each of the 3 ORs highlighted in bold for that SNP. If ICR CI seemed significant but numbers of cases and controls were too sparse, SNP was judged to have insufficient evidence of interaction with alcohol, and was not included in this table.

  • bORs for each SNP*drinking category were calculated from conditional logistic regression models including one SNP coded for dominant genetic model, categorized lifetime ethanol consumption, conditioned on sex, race, and age category, and adjusted for continuous smoking duration rounded to whole years. ORs highlighted in bold were used to calculate the ICR.

  • cICRs that are statistically significant after Bonferroni correction are highlighted in bold. Bonferroni correction for 64 statistical tests.