Table 3.

Association of IGF-I, IGFBP-3 concentrations IGF-I, IGFBP-3, and molar IGF-I/IGFBP-3 ratio with risk of high-grade and low-grade gliomas in EPIC, 1994–2006

Low-grade gliomaHigh-grade glioma
CategoryaCases/controlsORb (95% CI)ORc (95% CI)Cases/controlsORb (95% CI)ORc (95% CI)
IGF-I
 113/331.001.0045/931.001.00
 218/331.45 (0.59–3.56)1.94 (0.71–5.27)70/1091.34 (0.83–2.18)1.18 (0.71–1.96)
 317/391.19 (0.45–3.15)1.79 (0.60–5.36)44/1160.77 (0.46–1.32)0.62 (0.35–1.11)
 426/401.75 (0.68–4.48)3.60 (1.11–11.7)49/951.04 (0.60–1.80)0.79 (0.41–1.52)
log21.24 (0.60–2.58)2.72 (0.94–7.90)1.11 (0.74–1.66)0.81 (0.40–1.62)
Exclude first year of follow-up
 112/251.001.0041/861.001.00
 214/271.11 (0.41–3.02)1.23 (0.40–3.76)63/1001.32 (0.80–2.20)1.19 (0.70–2.02)
 315/250.89 (0.32–2.50)1.17 (0.36–3.83)42/1080.80 (0.46–1.39)0.67 (0.37–1.23)
 422/361.23 (0.45–3.36)2.05 (0.59–7.13)47/901.06 (0.60–1.88)0.87 (0.44–1.72)
log20.99 (0.46–2.15)2.31 (0.73–7.32)1.17 (0.77–1.77)1.34 (0.79–2.29)
IGFBP-3
 121/341.001.0045/1111.001.00
 214/240.92 (0.40–2.11)0.65 (0.26–1.60)62/1091.41 (0.89–2.23)1.57 (0.95–2.59)
 321/440.72 (0.32–1.62)0.48 (0.19–1.21)54/941.44 (0.87–2.39)1.76 (0.99–3.13)
 418/450.57 (0.24–1.37)0.28 (0.09–0.84)47/1001.19 (0.71–2.00)1.51 (0.80–2.83)
log20.58 (0.22–1.52)0.22 (0.05–0.93)0.93 (0.55–1.59)1.23 (0.73–2.06)
Exclude first year of follow-up
 117/281.001.0043/1031.001.00
 213/191.09 (0.44–2.69)0.90 (0.34–2.39)57/971.41 (0.87–2.28)1.54 (0.91–2.60)
 319/400.74 (0.32–1.75)0.62 (0.23–1.68)49/881.34 (0.80–2.26)1.56 (0.86–2.81)
 414/380.54 (0.21–1.38)0.34 (0.11–1.07)44/961.11 (0.65–1.90)1.31 (0.68–2.51)
log20.45 (0.15–1.31)0.19 (0.04–0.96)0.95 (0.54–1.68)0.74 (0.36–1.53)
IGF-I/IGFBP-3 ratio
 165/1321.0049/971.00
 279/1351.17 (0.76–1.82)63/1011.18 (0.71–1.97)
 353/1510.70 (0.42–1.16)40/1100.67 (0.37–1.21)
 485/1401.18 (0.71–1.95)56/1050.95 (0.53–1.71)
log21.46 (0.92–2.30)1.23 (0.74–2.05)
Exclude first year of follow-up
 114/301.0046/921.00
 212/261.04 (0.39–2.74)55/921.15 (0.68–1.96)
 313/360.90 (0.33–2.47)39/990.74 (0.40–1.36)
 424/312.01 (0.68–5.92)53/1010.95 (0.52–1.75)
log22.33 (0.76–7.09)1.34 (0.79–2.28)
  • aCut-points for quartiles: IGF-1: <199.60, 199.60–252.28, 252.29–313.99, ≥314.00 ng/mL; IGFBP-3: <4,074.90, 4,074.90–4,810.39, 4,810.40–5,551.89, ≥5,551.90 ng/mL; molar IGF-1/IGFBP-3 ratio: <2.08, 2.08–2.48, 2.49–2.93, ≥2.94;

  • bAnalysis matched on EPIC recruitment center, sex, age at blood donation, time of the day at blood donation, and fasting status;

  • cIGF-I adjusted for IGFBP-3 and vice versa.