Table 4.

Associations between 10-year supplemental mineral intake and risk of hematologic malignancies

10-y average daily use prior to baselineaCases, n (%)Noncases, n (%)Age- and sex-adjusted HR (95% CI)Multivariable adjusted HR (95% CI)b
Calcium
 None162 (27.7)17,607 (27.0)1.00 (reference)1.00 (reference)
 1.7–127.3 mg/d161 (27.5)16,287 (25.0)1.11 (0.89–1.39)1.15 (0.91–1.45)
 127.3–318.6 mg/d130 (22.2)15,797 (24.2)0.88 (0.70–1.12)0.88 (0.69–1.13)
 318.7–1,950.0 mg/dc132 (22.6)15,509 (23.8)0.96 (0.75–1.22)0.98 (0.76–1.27)
Ptrend0.3590.438
Iron
 None220 (37.9)23,571 (36.4)1.00 (reference)1.00 (reference)
 0.1–4.0 mg/d130 (22.4)13,777 (21.3)1.02 (0.82–1.27)1.04 (0.83–1.32)
 4.1–18.0 mg/d208 (35.9)24,799 (38.3)0.93 (0.76–1.12)0.93 (0.76–1.14)
 18.1–68.0 mg/dc22 (3.8)2,563 (4.0)1.09 (0.70–1.70)1.12 (0.71–1.76)
Ptrend0.5850.668
Magnesium
 None208 (35.5)22,023 (33.8)1.00 (reference)1.00 (reference)
 1.1–50.0 mg/d151 (25.8)17,881 (27.4)0.98 (0.79–1.21)1.00 (0.80–1.25)
 50.1–100.0 mg/d180 (30.7)19,620 (30.1)0.93 (0.76–1.14)0.94 (0.76–1.16)
 100.1–500.0 mg/dc47 (8.0)5,639 (8.7)0.90 (0.66–1.24)0.93 (0.66–1.30)
Ptrend0.4100.495
Zinc
 None207 (35.2)21,834 (33.5)1.00 (reference)1.00 (reference)
 0.32–7.50 mg/d141 (24.0)17,214 (26.4)0.95 (0.77–1.18)0.97 (0.77–1.21)
 7.51–15.0 mg/d154 (26.2)17,650 (27.1)0.89 (0.72–1.10)0.90 (0.72–1.13)
 15.1–130.0 mg/dc86 (14.6)8,475 (13.0)1.01 (0.78–1.30)0.99 (0.75–1.29)
Ptrend0.6600.625
Selenium
 None208 (35.6)22,932 (35.1)1.00 (reference)1.00 (reference)
 0.21–10.10 μg/d123 (21.1)14,228 (21.8)1.05 (0.84–1.31)1.07 (0.84–1.35)
 10.11–20.0 μg/d113 (19.4)12,697 (19.5)0.96 (0.76–1.20)0.96 (0.75–1.22)
 20.1–400.0 μg/dc140 (24.0)15,407 (23.6)0.97 (0.78–1.20)0.95 (0.75–1.20)
Ptrend0.6500.556
Chromium
 None220 (37.5)23,427 (35.9)1.00 (reference)1.00 (reference)
 0.2–34.0 μg/d119 (20.3)14,173 (21.7)1.00 (0.80–1.25)1.02 (0.80–1.29)
 34.1–130.0 μg/d228 (38.8)25,566 (39.2)0.93 (0.77–1.11)0.94 (0.77–1.14)
 130.1–393.0 μg/dc20 (3.4)2,094 (3.2)0.94 (0.60–1.49)0.86 (0.52–1.44)
Ptrend0.4220.437
  • aFrom single supplements (and mixtures other than multivitamins) plus multivitamins. See Design and Methods for how 10-year average dose was computed and categorized.

  • bAll models adjusted for age, sex, race/ethnicity, education, smoking, self-reported health, consumption of fruits and vegetables (without potatoes), history of coronary artery disease, history of rheumatoid arthritis, history of fatigue/lack of energy, and family history of leukemia/lymphoma. The model for iron was additionally adjusted for anemia within the last year prior to baseline.

  • cGreater than amount of that nutrient that could be obtained from 10-year daily use of the multivitamin Centrum Silver.