Table 4.

ORs and 95% CI for the risk of lung cancer for all cases and controls and for current smokers in the EPIC lung cancer study

SNPsExpected effect on lung cancer (8, 13, 17, 18)Effect alleleCasesControlsUnadjusted modelModel adjusted for cotinineaModel adjusted for regression dilution bias–corrected cotininea
OR (95% CI)POR (95% CI)POR (95% CI)P
All cases and controls
 rs215614 (7p14, PDE1C)G8191,6431.03 (0.91–1.18)0.611.06 (0.91–1.23)0.471.07 (0.91–1.24)0.42
 rs13273442 (8p11, CHRNB3)A8201,6460.98 (0.85–1.14)0.831.03 (0.87–1.220.731.03 (0.87–1.23)0.72
 rs1329650 (10q23)n/aT8011,5681.07 (0.93–1.24)0.341.06 (0.89–1.25)0.531.05 (0.89–1.25)0.55
 rs1028936 (10q23)n/aC8191,6491.02 (0.87–1.19)0.851.04 (0.86–1.26)0.671.05 (0.87–1.27)0.62
 rs16969968 (15q25, CHRNA5)A8681,7491.31 (1.16–1.48)<0.0011.26 (1.09–1.45)0.0021.23 (1.06–1.42)0.01
 rs578776 (15q25, CHRNA3)A8121,6580.79 (0.69–0.91)0.0010.85 (0.72–1)0.060.87 (0.74–1.03)0.10
 rs4105144 (19q13, CYP2A6)T8101,6350.93 (0.82–1.06)0.290.87 (0.75–1.02)0.090.86 (0.74–1.01)0.06
 rs3733829 (19q13)No effectG8111,6471.05 (0.92–1.19)0.461.14 (0.98–1.33)0.091.15 (0.99–1.34)0.07
 rs7937 (19q13, RAB4B)C8111,6380.88 (0.77–1.00)0.050.84 (0.72–0.98)0.020.83 (0.71–0.97)0.02
 rs7260329 (19q13, CYP2B6)T8211,6400.90 (0.79–1.03)0.120.98 (0.84–1.14)0.760.99 (0.84–1.15)0.86
Current smokersb
 rs215614 (7p14, PDE1C)G4843680.95 (0.77–1.17)0.620.99 (0.79–1.23)0.921.03 (0.81–1.31)0.81
 rs13273442 (8p11, CHRNB3)A4803730.98 (0.78–1.24)0.901.00 (0.77–1.28)0.981.01 (0.78–1.30)0.96
 rs1329650 (10q23)n/aT4703641.16 (0.94–1.44)0.181.14 (0.90–1.43)0.281.08 (0.85–1.38)0.53
 rs1028936 (10q23)n/aC4823751.05 (0.82–1.34)0.721.07 (0.82–1.4)0.621.11 (0.85–1.46)0.44
 rs16969968 (15q25, CHRNA5)A5113981.39 (1.15–1.69)<0.0011.22 (0.99–1.5)0.061.06 (0.77–1.46)0.72
 rs578776 (15q25, CHRNA3)A4693750.68 (0.53–0.86)0.0010.74 (0.57–0.95)0.020.84 (0.60–1.18)0.32
 rs4105144 (19q13, CYP2A6)T4803650.85 (0.70–1.04)0.120.74 (0.59–0.92)0.010.65 (0.48–0.88)0.005
 rs3733829 (19q13)No effectG4753711.13 (0.92–1.39)0.231.23 (0.99–1.54)0.071.31 (1.03–1.68)0.03
 rs7937 (19q13, RAB4B)C4823710.85 (0.70–1.03)0.100.76 (0.62–0.94)0.010.71 (0.56–0.90)0.005
 rs7260329 (19q13, CYP2B6)T4863660.85 (0.69–1.05)0.140.8 (0.65–1.03)0.090.81 (0.64–1.02)0.07

NOTE: ORs and 95% CIs for the SNPs were calculated by using conditional to matching variables logistic regression.

Abbreviation: n/a, no available information on effect of the SNP on lung cancer risk.

  • aModel was adjusted by continuous cotinine variable.

  • bUnconditional logistic regression adjusted for matching variables (year of birth, year of blood donation, gender, and country).