Table 2.

Characteristics of SNPs selected for genotyping

SNPsLocusGeneMinor alleleMAFPreviously observed effects of SNPs on CPD (8, 6) or CPD levels (1–10 CPD, 11–20, 21–30, and ≥31; ref. 7
βPReferences
rs215614a7p14PDE1CG0.360.222 × 10−78
rs13273442b8p11CHNB3A0.23−0.294 × 10−88
rs132965010q23LOC100188947T0.29−0.376 × 10−106
rs102893610q23LOC100188947C0.19−0.451 × 10−96
rs1696996815q25CHRNA5A0.391.006 × 10−726
0.084 × 10−657
rs57877615q25CHRNA3A0.27−0.067 × 10−377
rs410514419q132 kb 5′ CYP2A6T0.35−0.392 × 10−128
rs373382919q13EGLNG0.360.331 × 10−86
rs793719q13UTR RAB4BC0.46−0.242 × 10−98
rs726032919q13Intron, CYP2B6T0.32−0.205 × 10−68

Abbreviations: MAF, minor allele frequency; UTR, untranslated region.

  • aGenotyped instead of proxy rs215605 (r2 = 1.0; D′ = 1.0).

  • bGenotyped instead of proxy SNPs rs6474412 (r2 = 1.0; D′ = 1, effect on CPD β = 0.30, SE = 0.05, P = 1.7 × 10−8; ref. 8) and rs13280604 (r2 = 1.0; D′ = 1.0, effect on CPD β = 0.31, SE = 0.05, P = 1.3 × 10−8; ref. 8).