Table 2.

Associations between baseline characteristics and risk of hematologic malignancies

CharacteristicCases (n = 588), n (%)Noncases (n = 65,639), n (%)Age- and sex-adjusted HR (95% CI)
Demographic factors
Age at baseline, y, n (%)N/A
 <5547 (8.0)16,459 (25.1)
 55 to <60111 (18.9)15,531 (23.7)
 60 to <6597 (16.5)11,945 (18.2)
 65 to <70123 (20.9)10,339 (15.8)
 ≥70210 (35.7)11,365 (17.3)
Gender, n (%)
 Female232 (39.5)33,408 (50.9)1.00 (reference)
 Male356 (60.5)32,231 (49.1)1.67 (1.42–1.98)
Race/ethnicity, n (%)
 White544 (94.0)60,047 (93.0)1.00 (reference)
 Hispanic8 (1.4)577 (0.9)1.81 (0.90–3.65)
 Other27 (4.7)3,916 (6.1)0.80 (0.54–1.18)
Education, n (%)
 High school graduate or less127 (21.9)12,532 (19.4)1.00 (reference)
 Some college200 (34.5)24,711 (38.3)0.96 (0.77–1.20)
 College or advanced degree252 (43.5)27,316 (42.3)1.08 (0.86–1.34)
Lifestyle
Smoking status
 Never smoker, n (%)259 (44.1)31,381 (47.8)
 Pack-years,a mean (SD)28.1 (24.0)25.6 (23.2)1.00 (0.99–1.00)
Medical history
Self-reported health, n (%)
 Excellent66 (11.5)10,234 (15.8)1.00 (reference)
 Very good218 (37.9)25,507 (39.5)1.24 (0.94–1.63)
 Good209 (36.3)21,608 (33.4)1.34 (1.02–1.77)
 Fair67 (11.7)6,254 (9.7)1.50 (1.07–2.10)
 Poor15 (2.6)1,029 (1.6)2.34 (1.34–4.09)
History of coronary artery disease, n (%)
 No499 (84.9)59,913 (91.3)1.00 (reference)
 Yes89 (15.1)5,712 (8.7)1.25 (0.98–1.59)
History of rheumatoid arthritis, n (%)
 No551 (93.7)63,200 (96.3)1.00 (reference)
 Yes37 (6.3)2,425 (3.7)1.60 (1.14–2.24)
History of fatigue/lack of energy, n (%)
 No480 (81.6)53,911 (82.2)1.00 (reference)
 Yes108 (18.4)11,714 (17.8)1.16 (0.94–1.43)
History of anemia, n (%)
 No565 (96.1)64,181 (97.8)1.00 (reference)
 Yes23 (3.9)1,444 (2.2)2.17 (1.42–3.30)
Family history of leukemia/lymphoma, n (%)
 None533 (93.0)61,335 (94.6)1.00 (reference)
 1 first-degree relative34 (5.9)3,346 (5.2)1.15 (0.81–1.62)
 ≥2 first-degree relatives6 (1.0)147 (0.2)4.13 (1.84–9.25)
  • aAmong smokers and former smokers.