Table 2.

Characteristics of breast cancer recurrence cases and matched breast cancer controls according to tumor and treatment variables and UGT genotypes

ER+/TAM+, n (%)ER/TAMGroup, n (%)
CasesControlsCasesControls
UGT2B15*2 genotype
 2 normal alleles151 (29)140 (27)85 (29)87 (30)
 1 variant allele237 (45)238 (46)133 (46)130 (45)
 2 variant alleles133 (26)139 (27)71 (25)69 (24)
(Missing)20241114
UGT2B7*2 genotype
 2 normal alleles127 (25)113 (22)53 (19)63 (22)
 1 variant allele224 (44)232 (46)142 (50)142 (50)
 2 variant alleles163 (32)162 (32)87 (31)77 (27)
 (Missing)27341818
UGT1A8*3 genotype
 2 normal alleles502 (96)494 (95)284 (97)283 (97)
 1 variant allele19 (3.6)23 (4.4)8 (2.7)9 (3.1)
 2 variant alleles1 (0.2)1 (0.2)0 (0)0 (0)
 (Missing)192388
CYP2D6 phenotype
 Normal function (2 normal alleles)299 (61)308 (62)167 (60)173 (62)
 Reduced function (1 or 2 variant alleles)195 (39)189 (38)110 (40)107 (38)
Diagnosis yeara
 1985–1993235 (43)234 (43)107 (36)100 (33)
 1994–1996113 (21)112 (21)81 (27)83 (28)
 1997–2001193 (36)195 (36)112 (37)117 (39)
Age at diagnosis, y
 35–4416 (3.0)13 (2.4)68 (23)58 (19)
 45–54116 (21)111 (21)120 (40)113 (38)
 55–64286 (53)281 (52)82 (27)86 (29)
 65–69123 (23)136 (25)30 (10)43 (14)
Menopausal status at diagnosisa
 Premenopausal34 (6.3)34 (6.3)121 (40)121 (40)
 Postmenopausal507 (94)507 (94)179 (60)179 (60)
UICC tumor stage at diagnosisa
 I9 (1.7)9 (1.7)25 (8.3)25 (8.3)
 II250 (46)250 (46)153 (51)153 (51)
 III282 (52)282 (52)122 (41)122 (41)
Histologic grade
 I108 (25)144 (35)27 (11)23 (10)
 II234 (54)215 (52)125 (49)98 (43)
 III92 (21)57 (14)103 (40)106 (47)
 (Missing)1071254573
Type of surgery
 Mastectomy483 (89)470 (87)252 (84)244 (81)
 Breast-conserving58 (11)71 (13)47 (16)56 (19)
 (Missing)0010
Radiation therapy
 Yes183 (34)191 (35)128 (44)123 (47)
 No358 (66)350 (65)166 (56)137 (53)
 (Missing)00640
Adjuvant systemic chemotherapy
 Yes70 (13)65 (12)248 (83)188 (63)
 No471 (87)476 (88)52 (17)112 (37)
ER expression at centralized re-assay
 Positive451 (92)474 (96)72 (26)70 (25)
 Negative37 (7.6)19 (3.9)204 (74)205 (75)
 Not available53482425
  • aVariable used to match control subjects to recurrence cases by using risk-set sampling.