Association between serum 25(OH)D categories and risk of prostate cancer, ATBC Study
| Quintiles of 25(OH)Da | Ptrend | |||||
|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | ||
| Season-specific | ||||||
| Cases/controls, n | 168/201 | 201/200 | 208/199 | 197/200 | 225/199 | |
| ORb (95% CI) | 1.00 (reference) | 1.29 (0.95–1.74) | 1.34 (1.00–1.80) | 1.26 (0.93–1.72) | 1.56 (1.15–2.12) | 0.01 |
| Season-adjusted | ||||||
| Cases/controls, n | 174/200 | 198/200 | 193/199 | 218/200 | 216/200 | |
| ORb (95% CI) | 1.00 (reference) | 1.17 (0.87–1.57) | 1.12 (0.84–1.51) | 1.34 (0.99–1.82) | 1.36 (1.01–1.82) | 0.03 |
| Categories of 25(OH)D, nmol/L | ||||||
| <25 | 25 to <37.5 | 37.5 to <50 | 50 to <75 | ≥75 | ||
| Clinically predefined | ||||||
| Cases/controls, n | 299/327 | 255/241 | 195/190 | 194/195 | 56/46 | |
| ORb (95% CI) | 0.81 (0.60–1.08) | 0.94 (0.71–1.26) | 0.96 (0.71–1.31) | 1.00 (reference) | 1.16 (0.73–1.86) | 0.07 |
aCutoff -points for season-specific quintiles were Q1 ≤16.3, Q2 >16.3 and ≤23.8, Q3 >23.8 and ≤33.3, Q4 >33.3 and ≤45.6, Q5 >45.6 nmol/L for the less sunny months; Q1 ≤25.9, Q2 >25.9 and ≤35.7, Q3 >35.7 and ≤48.3, Q4 >48.3 and ≤59.9, Q5: >59.9 nmol/L for sunnier months. Cutoff points for season-adjusted quintiles were Q1 ≤3.00, Q2 >3.00 and ≤3.34, Q3 >3.34 and ≤3.63, Q4 >3.63 and ≤3.92, Q5 >3.92 residual units.
bORs based on conditional logistic regression. Models conditioned on the matching factors and adjusted for age, family history of prostate cancer, and serum α-tocopherol.