Table 3.

Association between serum 25(OH)D categories and risk of prostate cancer, ATBC Study

Quintiles of 25(OH)DaPtrend
12345
Season-specific
Cases/controls, n168/201201/200208/199197/200225/199
 ORb (95% CI)1.00 (reference)1.29 (0.95–1.74)1.34 (1.00–1.80)1.26 (0.93–1.72)1.56 (1.15–2.12)0.01
Season-adjusted
Cases/controls, n174/200198/200193/199218/200216/200
 ORb (95% CI)1.00 (reference)1.17 (0.87–1.57)1.12 (0.84–1.51)1.34 (0.99–1.82)1.36 (1.01–1.82)0.03
Categories of 25(OH)D, nmol/L
<2525 to <37.537.5 to <5050 to <75≥75
Clinically predefined
Cases/controls, n299/327255/241195/190194/19556/46
 ORb (95% CI)0.81 (0.60–1.08)0.94 (0.71–1.26)0.96 (0.71–1.31)1.00 (reference)1.16 (0.73–1.86)0.07
  • aCutoff -points for season-specific quintiles were Q1 ≤16.3, Q2 >16.3 and ≤23.8, Q3 >23.8 and ≤33.3, Q4 >33.3 and ≤45.6, Q5 >45.6 nmol/L for the less sunny months; Q1 ≤25.9, Q2 >25.9 and ≤35.7, Q3 >35.7 and ≤48.3, Q4 >48.3 and ≤59.9, Q5: >59.9 nmol/L for sunnier months. Cutoff points for season-adjusted quintiles were Q1 ≤3.00, Q2 >3.00 and ≤3.34, Q3 >3.34 and ≤3.63, Q4 >3.63 and ≤3.92, Q5 >3.92 residual units.

  • bORs based on conditional logistic regression. Models conditioned on the matching factors and adjusted for age, family history of prostate cancer, and serum α-tocopherol.