Table 1.

Summary of prostate cancer–associated SNPs discovered in GWAS and replicated in men of African descent

Gene	rs number	Position^a	Implicated in GWAS	Replication Study design	Disease phenotype	Risk allele	Association test OR (95% CI)	P	Reference	Correction for ancestry
3p12	rs2660753	87,193,364	Eeles et al., 2008 (10)	Case–control (868 cases and 878 controls)	Sporadic prostate cancer	T	OR (T allele) = 1.17 (1.02–1.35)	0.029	Xu et al., 2009 (11)	Model adjusted for age, ancestry proportion, and study population
7p15.2 (JAZF1)	rs10486567	27,943,088	Thomas et al., 2008 (12)	Nested case–control (860 cases and 575 controls)	Sporadic prostate cancer	G	OR (G allele) = 1.18 (1.00–1.40)	–	Waters et al., 2009 (13)	Models adjusted for age and proportion of European ancestry
				Multicenter sample (2,899 cases and 2,538 controls)	Sporadic prostate cancer	C	OR (C allele) = 1.18 (1.08–1.29)	0.0002	Chang et al., 2011 (14)	Model adjusted for age and study center
8q24	rs16901979	128,194,098	Gudmundsson et al., 2007 (15)	Case–control (868 cases and 878 controls)	Sporadic prostate cancer	A	OR (A allele) = 1.38 (1.19–1.60)	1.7E-05	Xu et al., 2009 (11)	Model adjusted for age, ancestry proportion, and study population
				Multicenter sample (2,642 cases and 2,584 controls)	Sporadic prostate cancer	A	OR (A allele) = 1.39 (1.28–1.52)	1.9 E-14	Chang et al., 2011 (14)	Model adjusted for age and study center
				Hospital-based case–control (490 cases and 567 controls)	Sporadic prostate cancer	A	OR (A allele) = 1.5 (1.1–2.2)	0.008	Robbins et al., 2007 (16)	Model adjusted for age and global and local 8q24 ancestry
				Community-based case–control (127 cases and 345 controls)	Sporadic prostate cancer	A	OR (A allele) = 1.60 (1.17–2.19)	0.003	Wang et al., 2010 (17)	None^b
				Case–control (338 cases and 426 controls)	Sporadic prostate cancer	A	OR (A allele) = 1.41 (1.02–1.95)	0.03	Okobia et al, 2011 (18)	None
				Case–control (156 cases and 231 controls)	Early onset prostate cancer (diagnosed among 65 years and younger)	A	OR (A allele) = 2.30 (1.40–3.77)	0.001	Okobia et al., 2011 (18)	None
	rs10086908	128,081,119	Al Olama et al., 2009 (19)	Case–control (868 cases and 878 controls)	Sporadic prostate cancer	T	OR (T allele) = 1.31 (1.11–1.55)	1.1E-03	Xu et al., 2009 (11)	Model adjusted for age, ancestry proportion, and study population
				Multicenter sample (861 cases and 876 controls)	Sporadic prostate cancer	T	OR (T allele) = 1.31 (1.11–1.54)	0.001	Chang et al., 2011 (14)	Model adjusted for age and study center
	rs13254738	128,173,525	Ghoussaini et al., 2008 (20)	Case–control (868 cases and 878 controls)	Sporadic prostate cancer	C	OR (C allele) = 1.36 (1.17–1.58)	4.9E-05	Xu et al., 2009 (11)	Model adjusted for age, ancestry proportion, and study population
				Multicenter sample (2,557 cases and 2,277 controls)	Sporadic prostate cancer	C	OR (C allele) = 1.29 (1.18–1.41)	1.03 × 10⁻⁸	Chang et al., 2011 (14)	Model adjusted for age and study center
				Nested case–control (1,614 cases and 837 controls	Sporadic prostate cancer	C	OR (C allele) = 1.24 (1.09–1.42)	–	Haiman et al., 2007 (21)	Model adjusted for genome-wide European ancestry and study
	rs6983561	128,176,062	Al Olama et al., 2009 (19)	Case–control (868 cases and 878 controls)	Sporadic prostate cancer	C	OR (C allele) = 1.31 (1.13–1.52)	2.8E-04	Xu et al., 2009 (11)	Model adjusted for age, ancestry proportion, and study population
				Multicenter sample (2,764 cases and 3,255 controls)	Sporadic prostate cancer	C	OR (C allele) = 1.37 (1.27–1.49)	3.5 E-15	Chang et al., 2011 (14)	Model adjusted for age and study center
				Community-based case–control (127 cases and 345 controls)	Sporadic prostate cancer	C	OR (C allele) = 1.55 (1.15–2.09)	0.0039	Wang et al., 2010 (17)	None^b
				Nested case–control (1,614 cases and 837 controls)	Sporadic prostate cancer	C	OR (C allele) = 1.34 (1.18–1.53)	–	Haiman et al., 2007 (21)	Model adjusted for genome-wide European ancestry and study
	rs7000448	128,510,352	Ghoussaini et al., 2008 (20)	Case–control (868 cases and 878 controls)	Sporadic prostate cancer	T	OR (T allele) = 1.20 (1.03–1.40)	0.016	Xu et al., 2009 (11)	Model adjusted for age, ancestry proportion, and study population
				Multicenter sample (1,698 cases and 2,329 controls)	Sporadic prostate cancer	T	OR (T allele) = 1.27 (1.15–1.41)	3.0 E-6	Chang et al., 2011 (14)	Model adjusted for age and study center
				Community-based case–control (127 cases and 345 controls)	Sporadic prostate cancer	T	OR (T allele) = 1.41 (1.03–1.94)	0.03	Wang et al., 2010 (17)	None^b
				Nested case–control (1,614 cases and 837 controls)	Sporadic prostate cancer	C	OR (C allele) = 1.33 (1.12–1.58)	–	Haiman et al., 2007 (21)	Model adjusted for genome-wide European ancestry and study
	rs6983267	128,482,487	Yeager et al., 2007 (22); Thomas et al., 2008 (12)	Multicenter sample (3,666 cases and 2,992 controls)	Sporadic prostate cancer	G	OR (G allele) = 1.32 (1.18–1.49)	3.3 E-6	Chang et al., 2011 (14)	Model adjusted for age and study center
				Population-based case study (417 cases and 925 Illumina controls)	Sporadic prostate cancer	T	OR (T allele) = 0.6 (0.4–0.7)	1.3 E-4	Xu et al., 2010 (23)	Model adjusted for proportion of West African ancestry
				Nested case–control (1,614 cases and 837 controls	Sporadic prostate cancer	G	1.43 (1.17–1.75)	–	Haiman et al., 2007 (21)	Model adjusted for genome-wide European ancestry and study
	rs1447295	128,554,220	Amundadottir et al., 2006 (24)	Multicenter sample (3,167 cases and 3,325 controls)	Sporadic prostate cancer	A	OR (A allele) = 1.11 (1.02–1.21)	0.014	Chang et al., 2011 (14)	Model adjusted for age and study center
				Case–control (171 cases and 256 cases)	Sporadic prostate cancer; diagnosed among men of 65 years and younger	A	OR AA genotype = 2.63 (1.14–6.05)		Schumacher et al., 2007 (25)	None
	rs10090154	128,601,319	Al Olama et al., 2009 (19)	Multicenter sample (1,683 cases and 1,403 controls)	Sporadic prostate cancer	T	1.20 (1.04–1.37)	0.011	Chang et al., 2011 (14)	Model adjusted for age and study center
	rs7017300	128,594,450	Eeles et al., 2008 (10)	Population-based case study (417 cases and 925 Illumina controls)	Sporadic prostate cancer	C	OR (C allele) = 1.2 (1.0–1.5)	0.03	Xu et al., 2010 (23)	Model adjusted for proportion of West African ancestry
10q11.2 MSMB	rs10993994	51,219,502	Eeles et al., 2008 (10)	Multicenter sample (3,374 cases and 2,982 controls)	Sporadic prostate cancer	T	OR (T allele) = 1.12 (1.03–1.21)	0.005	Chang et al., 2011 (14)	Model adjusted for age and study center
11q13	rs7931342	68,751,073	Eeles et al., 2008 (10)	Multicenter sample (2,445 cases and 2,018 controls)	Sporadic prostate cancer	G	OR (G allele) = 1.15 (1.03–1.29)	0.014	Chang et al., 2011 (14)	Model adjusted for age and study center
	rs10896449	68,751,243	Thomas et al., 2008 (12)	Multicenter sample (2,056 cases and 1,898 controls)	Sporadic prostate cancer	G	OR (G allele) = 1.12 (1.01–1.24)	0.031	Chang et al., 2011 (14)	Model adjusted for age and study center
				Hospital-based case–control (454 cases and 301 controls)	Sporadic prostate cancer	A	OR (A allele) = 0.7 (0.54–0.93)	0.009	Hooker et al., 2010 (26)	Model adjusted for IA estimates from 100 AIMs; same SNP not associated with aggressive disease
17q12 (HNF1B)	rs4430796	33,172,153	Gudmundsson et al., 2007 (27)	Hospital-based case–control study (364 cases and 353 controls)	Sporadic prostate cancer	T	OR (T allele) = 1.26 (1.01–1.56)	0.04	Sun et al., 2008 (28)	None^c
				Multicenter sample (3,112 cases and 2,911 controls)	Sporadic prostate cancer	T	OR (T allele) = 1.08 (1.00–1.18)	0.053	Chang et al., 2011 (14)	Model adjusted for age and study center
				Hospital-based case–control (454 cases and 301 controls)	Sporadic prostate cancer	A	OR (A allele) = 1.48 (1.11–1.96)	0.008	Hooker et al., 2010 (26)	IA estimates from 100 AIMs; same SNP not associated with aggressive disease
				Case–control (868 cases and 878 controls)	Sporadic prostate cancer	T	OR (T allele) = 1.16 (1.00-1.34)	0.056	Xu et al., 2009 (11)	Model adjusted for age, ancestry proportion, and study population
17q21 (ZNF652)	rs7210100	44,791,748	Haiman et al., 2011 (8)	Original GWAS in AA men			OR (per allele) = 1.51	3.4 × 10⁻¹³	–	Adjusted for age and ancestry
17q24.3	rs1859962	66,620,348	Eeles et al., 2008 (10)	Population-based case study (417 cases and 925 Illumina controls)	Sporadic prostate cancer	G	OR (G Allele) = 1.2 (1.0–1.5)	0.033	Xu et al., 2010 (23)	Model adjusted for proportion of West African ancestry
19q13.33 (KLK2 and KLK3)	rs2735839	56,056,435	Eeles et al., 2008 (10)	Hospital-based case–control (454 cases and 301 controls)	Sporadic prostate cancer	A	OR (A allele) = 0.78 (0.60–1.00)	0.04	Hooker et al., 2010 (26)	Model adjusted for IA estimates from 100 AIMs; same SNP not associated with aggressive disease
Xp11.22 (NUDT10/11)	rs5945572	51,246,423	Gudmundsson et al., 2008 (29)	Nested case–control (860 cases and 575 controls)	Sporadic prostate cancer	A	OR (A allele) = 1.34 (1.05–1.71)	–	Waters et al., 2009 (13)	Models adjusted for age and proportion of European ancestry
				Hospital-based case–control (454 cases and 301 controls)	Sporadic prostate cancer	A	1.48 (1.01–2.16)	0.05	Hooker et al., 2010 (26)	Model adjusted for IA estimates from 100 AIMs; same SNP not associated with aggressive disease
				Multicenter sample (1,764 cases and 1,235 controls)	Sporadic prostate cancer	A	OR (A allele) = 1.11 (1.02–1.20)	0.02	Chang et al., 2011 (14)	Model adjusted for age and study center
	rs5945619	51,258,412	Eeles et al., 2008 (10)	Multicenter sample (1,390 cases and 1,845 controls)	Sporadic prostate cancer	G	OR (G allele) = 1.09 (1.00–1.18)	0.039	Chang et al., 2011 (14)	Model adjusted for age and study center

Abbreviations: AA, African American; IA, individual ancestry; AIM, ancestry informative markers.

↵^aPosition based on NCBI Build 36.
↵^bStudy reports similar results found when adjusted for age and proportion of African ancestry.
↵^cStudy reports similar results found when models adjusted for proportion of African ancestry.