Table 2.

SNPs replicated in FPC/HPC

Geners numberPositionaImplicated in GWASReplication Study designDisease phenotypeRisk alleleAssociation test OR (95% CI)PReferenceModel description
Xp11rs594557251,246,423Gudmundsson et al., 2008 (29); Eeles et al., 2008 (10)168 HPC familiesHPC (≥2 first-degree affected family members)A0.009Lu et al., 2009 (30)P value reported for overtransmission from parents to affected offspring
rs594561951,258,412Eeles et al., 2008 (10)168 HPC familiesHPC (≥2 first-degree affected family members)C0.03Lu et al., 2009 (30)P value reported for overtransmission from parents to affected offspring
8q24rs1447295128,554,220Amundadottir et al., 2006 (24)Case–control (435 FPC cases and 545 population-based controls)FPC (families have ≥3 affected family members)AOR (A allele) = 1.93 (1.37–2.72)0.0004Wang L. et al., 2007 (31)None, similar results when adjusted for age
Hospital-based case–control study (221 HPC cases and 560 controls)HPC (≥2 first-degree affected family members)AORhom/het = 2.25 (1.52–3.32)4.8 × 10−5Sun J. et al., 2008 (32)Model adjusted for age
rs4242382128,586,755Thomas et al., 2008 (12)Hospital-based case–control study (221 HPC cases and 560 controls)HPC (≥2 first-degree affected family members)AORhom/het = 2.37 (1.61–3.50)1.39 × 10−5Sun J. et al., 2008 (32)Model adjusted for age
rs6983561128,176,062Al Olama et al., 2009 (19)Case–control (542 affected men and 473 of their unaffected brothers)FPC (men diagnosed with prostate cancer with ≥1 first- or second-degree living affected family memberCOR (C allele) = 2.26 (1.06–4.83)0.03Beebe-Dimmer J.L. et al., 2008 (33)None
Hospital-based case–control study (221 HPC cases and 560 controls)HPC (≥2 first-degree affected family members)CORhom/het = 1.76 (1.05–2.94)0.03Sun J. et al., 2008 (32)Model adjusted for age
rs6983267128,482,487Yeager et al., 2007 (22); Thomas et al., 2008 (12)Case–control (542 affected men and 473 of their unaffected brothers)FPC (men diagnosed with prostate cancer with ≥1 first- or second-degree living affected family memberGOR (G allele) = 1.30 (0.99–1.71)0.04Beebe-Dimmer J.L. et al., 2008 (33)None
rs7017300128,594,450Eeles et al., 2008 (10)Hospital-based case–control study 221 HPC cases and 560 controls)HPC (≥2 first-degree affected family members)CORhom/het = 1.86 (1.29–2.67)8.0 × 10−4Sun J. et al., 2008 (32)Model adjusted for age
rs7837688128,608,542Takata et al., 2010 (34)Hospital-based case–control study (221 HPC cases and 560 controls)HPC (≥2 first-degree affected family members)TORhom/het = 2.51 (1.71–3.70)3.2 × 10−6Sun J. et al., 2008 (32)Model adjusted for age
rs10090154128,601,319Al Olama et al., 2009 (19)Hospital-based case–control study (221 HPC cases and 560 controls)HPC (≥2 first-degree affected family members)TORhom/het = 2.33 (1.57–3.45)2.4 × 10−5Sun J. et al., 2008 (32)Model adjusted for age
rs16901979128,194,098Gudmundsson et al., 2007 (15)Hospital-based case–control study (221 HPC cases and 560 controls)HPC (≥2 first-degree affected family members)AORhom/het = 1.70 (1.02–2.84)0.04Sun J. et al., 2008 (32)Model adjusted for age
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