Table 1

Comparison of expression levels of IFNα/β signaling proteins in SCC and nonmalignant AS

The relative expression levels the ISGF3 proteins (STAT1α/β, STAT2, and p48), STAT3α, and STAT3β were scored visually on a scale of 1–4. Samples having a higher score in nonmalignant AS than in tumor (AS > T), equal scores in both (AS = T), or lower scores in AS than in tumor (AS < T) are indicated. Comparisons between AS and tumor tissue were made for contiguous tissues on the same slide and include samples of either primary SCC and AS (14 specimens from 11 patients) or metastases and overlying AS (2 specimens from 2 patients). Note that for patients 2, 3, and 9, two sections from different paraffin-embedded samples of the same tumor were stained. Due to variations in tumor biopsy sizes, the number of available sections was limited; therefore, it was not possible to probe all samples with each antibody. ND, not determined.

Patient no.Tumor typeSampleSTAT1α/βSTAT2p48STAT3αSTAT3β
1Primary SCCAAS = TAS > TAS > TAS > TAS = T
2” ”AAS > TNDNDAS > TAS > T
” ”BAS < TAS < TAS > TAS = TAS > T
3” ”AAS > TAS > TAS > TAS > TAS > T
” ”BAS > TAS = TAS > TAS > TAS = T
4” ”AAS = TAS > TAS > TAS > TAS > T
5” ”AAS = TAS = TAS = TNDND
6” ”AAS = TAS = TAS = TNDND
7” ”AAS > TAS > TAS > TNDND
8” ”AAS > TAS > TAS = TAS > TAS = T
9” ”AAS > TAS > TAS > TNDND
” ”BAS > TAS = TAS > TAS > TAS > T
10” ”AAS > TAS > TAS > TAS > TAS > T
11” ”AAS > TAS > TAS > TAS > TAS = T
12MetastasisAAS > TAS > TAS > TAS > TAS > T
9MetastasisAAS > TAS > TAS > TAS = TAS > T