Table 2

CYP1A1 I462V polymorphism in relation to lung cancer by smoking history and GSTM1 genotype among smokers

CategoryCasesControlsOR (95% CI)b
n%an%
All smokers184348
Ile/Ile14076.127378.41.00
Ile/Val3720.16619.01.09 (0.67–1.75)
Val/Val73.892.60.98 (0.33–2.94)
Ile/Val or Val/Val4423.97521.61.07 (0.68–1.68)
<20 cigarettes/day49188
Ile/Ile3571.415180.31.00
Ile/Val1428.63518.61.78 (0.85–3.75)
Val/Val00.021.1
Ile/Val or Val/Val1428.63719.71.72 (0.82–3.62)
20+ cigarettes/day135160
Ile/Ile10577.812276.31.00
Ile/Val2317.03119.40.84 (0.45–1.54)
Val/Val75.274.40.99 (0.32–3.06)
Ile/Val or Val/Val3022.23823.80.86 (0.49–1.51)
GSTM1 null98208
Ile/Ile6869.416478.81.00
Ile/Val2727.63717.81.69 (0.92–3.11)
Val/Val33.173.40.78 (0.19–3.26)
Ile/Val or Val/Val3030.64421.21.52 (0.86–2.71)
GSTM1 positive86140
Ile/Ile7283.710977.91.00
Ile/Val1011.62920.70.52 (0.23–1.16)
Val/Val44.721.41.72 (0.23–12.9)
Ile/Val or Val/Val1416.33122.10.60 (0.28–1.27)
GSTM1 null, <20 cigarettes/day31115
Ile/Ile2064.59481.71.00
Ile/Val or Val/Val1135.52118.32.80 (1.07–7.33)
GSTM1 null, 20+ cigarettes/day6793
Ile/Ile4871.67075.31.00
Ile/Val or Val/Val1928.42324.71.13 (0.55–2.34)
GSTM1 positive, <20 cigarettes/day1873
Ile/Ile1583.35778.11.00
Ile/Val or Val/Val316.71621.90.66 (0.17–2.65)
GSTM1 positive, 20+ cigarettes/day6867
Ile/Ile5783.85277.61.00
Ile/Val or Val/Val1116.21522.40.62 (0.25–1.55)
  • a Total may add up to less than 100% due to rounding. Smokers with missing data on GSTM1 genotype are excluded form analyses for this table (9 cases and 23 controls).

  • b ORs and 95% CIs are calculated relative to Ile/Ile homozygotes. Models include terms for smoking (past versus current) and continuous terms for age, number of cigarettes smoked per day, and age at starting to smoke.