Table 1

CYP1A1 I462V polymorphism in relation to lung cancer among a cohort of older middle aged men in Shanghai, China

CYP1A1 genotypeCasesControlsAge-adjusted ORbAge- and smoking-adjusted OR (95% CI)c
n%an%
All subjects214669
Ile/Ile16778.051276.51.001.00
Ile/Val3918.213019.40.930.95 (0.62–1.48)
Val/Val83.7274.00.910.85 (0.33–2.20)
Ile/Val or Val/Val4722.015723.50.930.94 (0.62–1.41)
Histologyd
Adenocarcinoma64
Ile/Ile5382.8
Ile/Val1117.20.800.83 (0.41–1.67)
Val/Val00
Ile/Val or Val/Val1117.20.660.70 (0.35–1.41)
Squamous & small cell74
Ile/Ile5473.0
Ile/Val1824.31.331.38 (0.74–2.55)
Val/Val22.70.710.58 (0.08–4.04)
Ile/Val or Val/Val2027.01.221.27 (0.70–2.31)
Other and unknown76
Ile/Ile6078.9
Ile/Val1013.20.680.69 (0.33–1.45)
Val/Val67.91.911.49 (0.50–4.48)
Ile/Val or Val/Val1621.10.890.84 (0.44–1.59)
  • a Totals may add to slightly more or less than 100% due to rounding.

  • b OR, calculated relative to Ile/Ile homozygotes. Age was modeled as a continuous variable.

  • c 95% CI. Smoking-adjusted model includes terms for number of cigarettes/day, age started smoking, and smoking status (never, past, or current).

  • d The comparison group for each histology category is all controls combined.