Association between type of H. pylori strain, CagA/VacA antibodies by immunoblotting, presence of cagA/vacA genes by PCR, and risk of gastric cancer
No. of cases | No. of controls | Gastric cancer risk | |
---|---|---|---|
OR (95% CI) | |||
By immunoblotting | |||
H. pylori nega | 15 | 105 | 1 (Reference) |
Type II strainb | 1 | 34 | 0.2 (0.0–1.8) |
Intermediate strainc | 34 | 102 | 2.0 (1.0–4.0) |
Type I straind | 16 | 67 | 1.8 (0.8–4.0) |
H. pylori nega | 15 | 105 | 1 (Reference) |
CagA neg | 2 | 39 | 0.4 (0.1–1.7) |
CagA pose | 49 | 164 | 1.9 (1.0–3.7) |
H. pylori nega | 15 | 105 | 1 (Reference) |
VacA neg | 34 | 131 | 1.6 (0.8–3.1) |
VacA pos | 17 | 72 | 1.8 (0.8–3.8) |
By PCR | |||
H. pylori nega | 43 | 198 | 1 (Reference) |
cagA neg | 1 | 13 | 0.4 (0.0–3.2) |
cagA pos | 27 | 113 | 1.2 (0.7–2.1) |
H. pylori nega | 43 | 198 | 1 (Reference) |
vacA s2 | 1 | 2 | 2.3 (0.2–27) |
vacA s1 | 27 | 124 | 1.1 (0.6–2.0) |
H. pylori nega | 43 | 198 | 1 (Reference) |
vacA m2 | 1 | 20 | 0.2 (0.0–1.8) |
vacA m1 | 24 | 99 | 1.2 (0.7–2.2) |
a H. pylori neg, negative on all tests performed.
b CagA and VacA negative.
c CagA positive or VacA positive.
d CagA and VacA positive by immunoblotting.
e pos, postive.