Table 3

Association between type of H. pylori strain, CagA/VacA antibodies by immunoblotting, presence of cagA/vacA genes by PCR, and risk of gastric cancer

No. of casesNo. of controlsGastric cancer risk
OR (95% CI)
By immunoblotting
H. pylori nega151051 (Reference)
Type II strainb1340.2 (0.0–1.8)
Intermediate strainc341022.0 (1.0–4.0)
Type I straind16671.8 (0.8–4.0)
H. pylori nega151051 (Reference)
CagA neg2390.4 (0.1–1.7)
CagA pose491641.9 (1.0–3.7)
H. pylori nega151051 (Reference)
VacA neg341311.6 (0.8–3.1)
VacA pos17721.8 (0.8–3.8)
By PCR
H. pylori nega431981 (Reference)
cagA neg1130.4 (0.0–3.2)
cagA pos271131.2 (0.7–2.1)
H. pylori nega431981 (Reference)
vacA s2 122.3 (0.2–27)
vacA s1 271241.1 (0.6–2.0)
H. pylori nega431981 (Reference)
vacA m2 1200.2 (0.0–1.8)
vacA m1 24991.2 (0.7–2.2)
  • a H. pylori neg, negative on all tests performed.

  • b CagA and VacA negative.

  • c CagA positive or VacA positive.

  • d CagA and VacA positive by immunoblotting.

  • e pos, postive.