Table 2

Combined segregation/linkage analysis of CMM, incorporating covariates TN, DN, and SI (MI method)

ModelAllele frequencyaCDKN2A+α(−)α(+)β(age)TNDNSI−2ln L
TN β(−)TN β(+)UnkTN β*DN β(−)DN β(+)UnkDN β*SI β(−)SI β(+)UnkSI β*
1. No sun-related covariates0.06−10.6−8.41.51438.90
2. TN added to model0.06−11.0−9.01.51.2[=β(−)]0.41413.23
2a. TN-CDKN2A interaction0.06−11.0−9.01.51.41.20.41413.05
3. DN added to model0.06−12.3−10.61.62.4[=β(−)]1.31386.55
3a. DN-CDKN2A interaction0.06−12.6−10.21.62.81.81.01382.27
4. SI added to model0.06−10.8−8.41.6−0.2[=β(−)]−0.51435.47
5. TN and DN added0.06−12.4−10.91.60.6[=β(−)]1.22.1[=β(−)]0.41373.03
5a. TN-CDKN2A inter; and DN0.06−12.3−11.01.60.40.81.32.1[=β(−)]0.41372.48
5b. DN-CDKN2A inter; and TN0.06−12.6−10.51.60.6[=β(−)]1.22.41.60.21370.78
  • a −, CDKN2A mutation absent; +, CDKN2A mutation present. α, genotype-specific baseline parameter [e.g., α(−) is CDKN2A mutation absent baseline parameter]; β, regression coefficients of covariates [e.g., TN β(+) is CDKN2A mutation present regression coefficient of TN];β

  • * , regression coefficient, not genotype specific.