Table 2

LH status of breast cancer cases and controls, NYU Women’s Health Study

LH statusBreast cancer cases (n = 270)Controls (n = 540)OR (95% CI)aOR (95% CI)b
Normal LH (wild type)239 (88.5%)482 (89.3%)1.001.00
Variant LH (heterozygotes)29 (10.7%)54 (10.0%)1.08 (0.68–1.72)1.11 (0.69–1.78)
Variant LH (homozygotes)2 (0.7%)4 (0.7%)1.00 (0.18–5.50)1.03 (0.18–5.71)
Variant LH (heterozygotes+ homozygotes)31 (11.5%)58 (10.7%)1.07 (0.68–1.69)1.10 (0.70–1.74)
  • a Adjusted only for matching factors.

  • b Adjusted for height, Quetelet index, age at menarche, age at first full-term pregnancy (all as continuous variables), history of a prior benign breast condition (positive versus negative), and first-degree family history of breast cancer (positive versus negative).