Table 2

Relative odds (and 95% CLs) of cervical cancer according to thirds of serum concentrations of folate, B12, and homocysteine, Washington County, Maryland, 1975–1990

Serum concentrationaFolateB12Homocysteine
MatchedbAdditional adjustmentscMatchedbAdditional adjustmentscMatchedbAdditional adjustmentsc
Lowd1.01.01.01.01.01.0
Middle0.86 (0.31, 2.39)0.62 (0.19, 1.98)1.12 (0.46, 2.73)0.97 (0.33, 2.84)0.64 (0.21, 1.98)0.92 (0.24, 3.53)
High0.61 (0.24, 1.60)0.60 (0.19, 1.88)0.47 (0.16, 1.40)0.53 (0.16, 1.75)2.17 (0.82, 5.77)2.67 (0.81, 8.82)
P for trend0.300.420.180.280.030.05
  • a The tertiles were 2.9 and 4.8 ng/ml for folate, 441.0 and 655.0 pg/ml for B12, and 8.6 and 10.4 nmol/ml for homocysteine.

  • b Adjusted for matching factors (age, race, and date of blood donation).

  • c Adjusted for matching factors plus education, current smoking, current oral contraceptive use, and HPV-16 positivity.

  • d Referent category.