Table 2

Multivariate ORs and 95% CIs for anthropometric variables with breast cancer risk according to the joint tumor ER/PR status in the studies of premenopausal and postmenopausal women, conducted in Los Angeles County, California

ControlsER+/PR+ER+/PR−ER−/PR−ER unknown/PR unknown
CasesOR(95% CI)CasesOR(95% CI)CasesOR(95% CI)CasesOR(95% CI)
Postmenopausala
BMI, reference age
<21.7266711.00341.00311.00901.00
21.7–23.62771011.36(0.96–1.94)381.12(0.68–1.85)361.19(0.71–1.99)880.95(0.67–1.36)
23.7–27.02751271.78(1.26–2.51)461.35(0.83–2.20)250.80(0.45–1.40)921.03(0.72–1.46)
≥27.12731512.45(1.73–3.47)411.29(0.78–2.15)351.20(0.70–2.05)1301.57(1.12–2.20)
Trend P0.00010.240.85b0.009
BMI, age 18
<21.77493071.001071.00911.002711.00
21.7–23.6222961.09(0.83–1.44)320.99(0.64–1.52)230.85(0.52–1.38)891.13(0.84–1.51)
23.7–27.083351.02(0.66–1.55)171.37(0.77–2.43)90.81(0.39–1.68)290.94(0.60–1.49)
≥27.137120.75(0.38–1.49)30.53(0.16–1.79)40.79(0.27–2.29)110.77(0.38–1.56)
Trend P0.820.980.400.77
% change from age 18 to reference age
≤0173481.00251.00141.00521.00
0.1–14.23081041.28(0.86–1.91)441.02(0.61–1.79)492.12(1.13–3.99)1041.19(0.80–1.76)
14.3–29.13031331.71(1.16–2.52)511.22(0.73–2.11)261.16(0.58–2.30)1051.22(0.82–1.81)
≥29.23071652.32(1.58–3.41)390.99(0.58–1.78)381.75(0.91–3.38)1391.71(1.16–2.53)
Trend P0.00010.870.610.004
Premenopausalc
BMI, reference age
<21.7319881.00171.00621.001401.00
21.7–23.6162541.28(0.86–1.89)172.19(1.09–4.39)351.11(0.71–1.77)640.89(0.63–1.28)
23.7–27.0115331.03(0.65–1.64)111.72(0.77–3.85)230.95(0.58–1.70)470.80(0.54–1.21)
≥27.1118341.11(0.70–1.77)60.92(0.34–2.47)251.07(0.56–1.68)450.80(0.53–1.20)
Trend P0.680.720.910.20
  • a Models include age at reference year, socioeconomic status, number of full-term pregnancies, months of breastfeeding, age at menopause, hormone replacement therapy, family history, alcohol consumption, and physical activity.

  • b 0.001 < P < 0.01 for difference in response function compared with ER+/PR+.

  • c Models include age at reference year, socioeconomic status, age at menarche, age at first full-term pregnancy, number of full-term pregnancies, months of breastfeeding, family history, and physical activity.