Table 3

MTHFR genotype interaction with RBC and plasma folate

RBC folatea ng/ml (n = 669)52.7–164.7164.8–228.2228.3–314.6314.7–1454P-trend
CC/CT
Case/Control81/9574/7863/8565/76
ORb1.00.860.690.800.22
95% CI(reference)(0.55–1.35)(0.43–1.08)(0.51–1.28)
TT
Case/Control9/47/611/912/14
ORb2.041.021.120.800.21
95% CI(0.60–6.96)(0.32–3.22)(0.44–2.87)(0.33–1.78)
P interaction0.45
Plasma folatec ng/ml (n = 691)2.0–5.785.8–9.519.52–17.417.5–56.6P-trend
CC/CT
Case/Control78/7475/7274/8569/870.14
ORb1.00.970.820.73
95% CI(reference)(0.62–1.54)(0.52–1.29)(0.46–1.15)
TT
Case/Control14/1715/115/96/100.04
ORb1.841.240.520.54
95% CI(0.60–6.96)(0.52–2.93)(0.16–1.64)(0.19–1.59)
P interaction0.14
  • a Four hundred three (196 cases and 207 controls) were missing values for RBC folate.

  • b Adjusted for age, gender, ethnicity, clinic, and exam date.

  • c Three hundred eighty-one (182 cases and 199 controls) were missing values for plasma folate.