Table 3

ORs for GSTM1, GSTT1, and GSTP1 genotypes and breast cancer, stratified by family history, hormone replacement therapy, alcohol consumption, and body mass index

GSTM1 Null ORa (95% CI)GSTM1 Present OR (95% CI)GSTT1 Null OR (95% CI)GSTT1 Present OR (95% CI)GSTP1 Val/Val OR (95% CI)GSTP1 Ile/Val OR (95% CI)GSTP1 Ile/Ile OR (95% CI)
Family historyb
No0.8 (0.6–1.0)Referent0.9 (0.6–1.2)Referent0.8 (0.5–1.2)0.8 (0.6–1.0)Referent
Yes2.1 (1.0–4.2)Referent1.9 (0.8–4.6)Referent0.6 (0.2–1.7)0.7 (0.4–1.5)Referent
Hormone replacement therapy
Never0.8 (0.6–1.1)Referent1.0 (0.7–1.5)Referent0.8 (0.5–1.2)0.8 (0.6–1.1)Referent
Ever1.1 (0.7–1.7)Referent0.9 (0.5–1.6)Referent0.8 (0.4–1.5)0.8 (0.5–1.3)Referent
Alcohol consumption
No1.0 (0.6–1.5)Referent0.9 (0.5–1.5)Referent0.6 (0.3–1.2)0.8 (0.5–1.2)Referent
Yes0.8 (0.6–1.1)Referent1.0 (0.7–1.5)Referent0.9 (0.6–1.3)0.8 (0.6–1.1)Referent
Body mass index
≤27.7 kg/m20.9 (0.7–1.3)Referent0.9 (0.6–1.3)Referent0.7 (0.4–1.2)0.9 (0.6–1.2)Referent
>27.7 kg/m20.8 (0.6–1.2)Referent1.0 (0.6–1.6)Referent0.8 (0.5–1.4)0.7 (0.5–1.1)Referent
  • a Adjusted for age and race.

  • b One or more first-degree relatives with breast cancer.