Table 5

GSTT1, GSTM1, and GSTP1 polymorphisms and RCC risk, by smoking history and BMI

GSTT1GSTM1GSTP1
Cases (%)Controls (%)OR95% CICases (%)Controls (%)OR95% CICases (%)Controls (%)OR95% CI
Smokinga
Never
Present27 (69.2)138 (79.3)1.0Present19 (48.7)86 (49.1)1.0AA17 (42.5)73 (45.0)1.0
Null12 (30.8)36 (20.7)2.30.9–5.7Null20 (51.3)89 (50.9)1.00.4–2.3AG or GG23 (57.5)93 (55.0)1.10.5–2.5
Ever
Present63 (72.4)273 (82.7)1.0Present44 (50.6)164 (49.7)1.0AA41 (45.6)137 (42.6)1.0
Null24 (27.6)57 (17.3)1.70.8–3.4Null43 (49.4)166 (50.3)1.00.6–1.8AG or GG49 (54.4)185 (57.5)0.90.5–1.6
BMIb (tertiles)
Low
Present17 (51.5)132 (81.0)1.0Present11 (33.3)78 (47.9)1.0AA12 (36.4)64 (40.8)1.0
Null16 (48.5)31 (19.0)4.81.8–13.0Null22 (66.7)85 (52.2)2.20.9–5.6AG or GG21 (63.6)93 (59.2)1.20.5–3.1
Middle
Present33 (73.3)141 (82.9)1.0Present23 (51.1)77 (45.2)1.0AA22 (47.8)75 (44.6)1.0
Null12 (26.7)29 (17.1)1.50.6–3.9Null22 (48.9)93 (54.7)0.70.3–1.6AG or GG24 (52.2)93 (55.4)1.10.5–2.3
High
Present40 (83.3)138 (80.7)1.0Present29 (60.4)95 (55.2)1.0AA24 (47.1)74 (44.6)1.0
Null8 (16.7)33 (19.3)1.00.3–2.7Null19 (39.6)77 (44.8)0.70.3–1.6AG or GG27 (52.9)92 (55.4)0.80.4–1.7
  • a ORs adjusted for age, sex, race, county, and BMI. Tests for interaction: GSTT1 genotype and never/ever smoking, P = 0.60; GSTM1 genotype and never/ever smoking, P = 0.97; GSTP1 genotype and never/ever smoking, P = 0.70.

  • b ORs adjusted for age, sex, race, pack-years smoking, and county. Tests for interaction: GSTT1 genotype and tertile BMI, P = 0.07; GSTM1 genotype and tertile BMI, P = 0.13; GSTP1 genotype and tertile BMI, P = 0.76.