Table 2

GST M1, T1, and P1 genotypes in RCC cases and controlsa by selected characteristics

nGSTM1 (% null)a,bGSTT1 (% null)a,bGSTP1 (% AG or GG)a,c
CasesControlsCaseControlCaseControlCaseControl
Sex
Male9440153.950.426.418.353.257.3
Female3610440.051.034.319.261.153.9
Age
<45 yr143957.151.314.318.064.375.7
45–54 yr268746.249.426.917.261.551.2
55–64 yr4618852.352.738.619.747.855.7
65–74 yr4419147.648.723.817.956.856.1
Race
White12148948.750.524.818.056.256.7
African American4275.050.075.050.050.050.0
Asian27100.042.9100.042.90.050.0
Native American230.033.350.00.050.033.3
Other14100.075.0100.025.0100.075.0
Country of birth
United States12046649.249.628.018.557.556.5
Other103962.561.537.518.030.058.3
Hispanic origin
No12849649.250.429.018.254.756.1
Yes29100.055.60.033.3100.087.2
County of residence
King615548.361.837.914.650.857.4
Pierce312041.945.022.620.067.745.0
Skagit372100.044.433.39.733.353.5
Snohomish2625257.748.811.517.157.759.3
Whatcom910650.053.837.529.344.454.4
Stage at diagnosis
Local7248.629.256.9
Regional3345.524.257.6
Distant2363.226.347.8
Unstaged250.0100.050.0
  • a Results from 132 cases and 505 controls with DNA available, of 173 cases and 614 controls interviewed. The number of subjects with genotype results was 126 cases and 505 controls for GSTM1; 126 cases and 504 controls for GSTT1; and 130 cases and 491 controls for GSTP1.

  • b Percentage of genotyped subjects in each category homozygous null for GSTM1 or GSTT1.

  • c Percentage of genotyped subjects in each category heterozygous or homozygous for GSTP1 exon 5 A/G.